N-DESMETHYLCLOZAPINE Chemical Properties

Melting point:

120-125°C

Boiling point:

502.6±60.0 °C(Predicted)

Density 

1.38±0.1 g/cm3(Predicted)

Flash point:

9℃

storage temp. 

Store at RT

solubility 

Chloroform (Slightly), DMSO, Methanol (Slightly)

pka

8.49±0.10(Predicted)

form 

Yellow solid.

color 

Light Yellow to Yellow

CAS DataBase Reference

6104-71-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,T,F

Risk Statements 

20/22-36/37/38-39/23/24/25-23/24/25-11

Safety Statements 

22-36-45-36/37-16-7

RIDADR 

3249

WGK Germany 

3

HazardClass 

6.1(b)

PackingGroup 

III

MSDS

• Language:English Provider:SigmaAldrich

N-DESMETHYLCLOZAPINE Usage And Synthesis

Chemical Properties

Yellow Crystalline Solid

Uses

A major metabolite of Clozapine. A potent and selective 5-HT2C serotonin receptor antogonist.

Uses

N-Desmethylclozapine has been used as standard to quantify the clozapine plasma levels in treatment-refractory Chinese schizophrenic patients.

Uses

A major metabolite of Clozapine (C587500). A potent and selective 5-HT2C serotonin receptor antogonist.

Definition

ChEBI: A dibenzodoazepine substituted with chloro and piperazino groups which is a major metabolite of clozapine; a potent and selective 5-HT2C serotonin receptor antagonist.

General Description

N-Desmethylclozapine is an active metabolite of Clozapine, an atypical antipsychotic drug used for treatment of schizophrenia. Clozapine is sold under the trade names Clozaril^? and FrazaClo in the US. This Certified Snap-N-Spike^? Solution is suitable for use in urine drug testing, clinical toxicology, forensic analysis, and clinical monitoring by LC-MS/MS or GC/MS.

Biological Activity

A major metabolite of clozapine; a potent and selective 5-HT 2C serotonin receptor antagonist.

Biochem/physiol Actions

N-Desmethylclozapine serves as an agonist to muscarinic acetylcholine receptors, and is known to exert its antipsychotic action. It blocks synaptic transmission by antagonizing synaptic GABA (γ-aminobutyric acid) receptors.

storage

Room temperature

N-DESMETHYLCLOZAPINE(6104-71-8)Related Product Information

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