3,4,5-Trimethoxytoluene Chemical Properties

Melting point:

24-26 °C (lit.)

Boiling point:

117-118 °C/5 mmHg (lit.)

Density 

1.082 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.523(lit.)

Flash point:

166 °F

storage temp. 

Sealed in dry,Room Temperature

form 

powder to lump to clear liquid

color 

White or Colorless to Light yellow

Specific Gravity

1.082

BRN 

1953791

LogP

1.819 (est)

CAS DataBase Reference

6443-69-2(CAS DataBase Reference)

NIST Chemistry Reference

Benzene, 1,2,3-trimethoxy-5-methyl-(6443-69-2)

Safety Information

Hazard Codes 

Xi

Safety Statements 

23-24/25

WGK Germany 

3

HS Code 

29093090

MSDS

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3,4,5-Trimethoxytoluene Usage And Synthesis

Chemical Properties

CLEAR YELLOW LIQUID

Uses

3,4,5-Trimethoxytoluene is a reagent for oxadiazolylindazole sodium channel modulators which are neuroprotective toward hippocampal neurons.

Uses

3,4,5-Trimethoxytoluene was used as a substructure model compound in the reaction of trimethoprim with free available chlorine (i.e. HOCl).

Definition

ChEBI: 3,4,5-Trimethoxytoluene is a member of methoxybenzenes.

Synthesis

Using 3,4,5-trimethoxybenzaldehyde as the starting material, referring to the synthesis method of Example 2, 10 g of 3,4,5-trimethoxybenzaldehyde was dissolved in 100 g of tetrahydrofuran, 1 g of Catalyst B was added, and the hydrogenation reaction was carried out under hydrogen atmosphere. Upon completion of the reaction, the aldehyde group conversion was confirmed to be 100% by testing. The isolated yield of the target product 3,4,5-trimethoxytoluene was 96% based on the initial addition of 3,4,5-trimethoxybenzaldehyde.

References

[1] Bioorganic Chemistry, 2016, vol. 68, p. 214 - 218
[2] Tetrahedron, 2007, vol. 63, # 38, p. 9382 - 9386
[3] Synthesis, 1993, # 8, p. 797 - 802
[4] Synthetic Communications, 2006, vol. 36, # 14, p. 1961 - 1965
[5] Journal of Chemical Research, 2010, vol. 34, # 12, p. 717 - 718

3,4,5-Trimethoxytoluene(6443-69-2)Related Product Information

• Benzotrifluoride
• Mesitylene
• (Trifluoromethoxy)benzene
• Trimethyl phosphite
• Trimethoxymethane
• Anisole
• 4-(Trifluoromethoxy)aniline
• 1,2,4-Trimethylbenzene
• Colchicine
• 3,4,5-Trimethoxyphenylacetic acid
• 3,4,5-Trimethoxyphenylacetonitrile
• 3,4,5-Trimethoxybenzoyl chloride
• 3,4,5-TRIMETHOXYCINNAMIC ACID
• 3,4,5-Trimethoxybenzonitrile
• 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID
• 3,4,5-Trimethoxybenzyl alcohol
• Methyl 3,4,5-trimethoxybenzoate
• 2,4,6-Trinitrotoluene