3,4,5-Trimethoxytoluene

Product Name: 3,4,5-Trimethoxytoluene
CAS No.: 6443-69-2
Chemical Name: 3,4,5-Trimethoxytoluene
Synonyms: TriMethoxytoluene;3,4,5-Trimethoxytolu;Trimethoprim Lactnte;3,4,5-trimethoxytoluen;3,4,5-Trimethoxytolune;3,4,5-TRIMETHOXYTOLUENE;Toluene, 3,4,5-trimethoxy-;3,4,5-Trimethoxytoluene,97%;5-Methyl-1,2,3-trimethoxybenzene;1,2,3-Trimethoxy-5-methylbenzene
CBNumber: CB8232173
Molecular Formula: C10H14O3
Formula Weight: 182.22
MOL File: 6443-69-2.mol

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3,4,5-Trimethoxytoluene Property

Melting point:: 24-26 °C (lit.)
Boiling point:: 117-118 °C/5 mmHg (lit.)
Density: 1.082 g/mL at 25 °C (lit.)
refractive index: n20/D 1.523(lit.)
Flash point:: 166 °F
storage temp.: Sealed in dry,Room Temperature
form: powder to lump to clear liquid
color: White or Colorless to Light yellow
Specific Gravity: 1.082
BRN: 1953791
InChI: 1S/C10H14O3/c1-7-5-8(11-2)10(13-4)9(6-7)12-3/h5-6H,1-4H3
InChIKey: KCIZTNZGSBSSRM-UHFFFAOYSA-N
SMILES: COc1cc(C)cc(OC)c1OC
LogP: 1.819 (est)
CAS DataBase Reference: 6443-69-2(CAS DataBase Reference)
NIST Chemistry Reference: Benzene, 1,2,3-trimethoxy-5-methyl-(6443-69-2)

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Safety

Hazard Codes: Xi
Safety Statements: 23-24/25
WGK Germany: 3
HS Code: 29093090
Storage Class: 10 - Combustible liquids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H227Combustible liquid
Precautionary statements: P403+P235Store in a well-ventilated place. Keep cool.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 227714
Product name: 3,4,5-Trimethoxytoluene
Purity: 97%
Packaging: 10g
Price: $45.85
Updated: 2025/07/31

TCI Chemical

Product number: T1236
Product name: 3,4,5-Trimethoxytoluene
Purity: >98.0%(GC)
Packaging: 25g
Price: $36
Updated: 2025/07/31

TCI Chemical

Product number: T1236
Product name: 3,4,5-Trimethoxytoluene
Purity: >98.0%(GC)
Packaging: 500g
Price: $262
Updated: 2023/06/20

TRC

Product number: T796245
Product name: 3,4,5-Trimethoxytoluene
Packaging: 1g
Price: $50
Updated: 2021/12/16

AK Scientific

Product number: J56015
Product name: 3,4,5-Trimethoxytoluene
Packaging: 25g
Price: $29
Updated: 2021/12/16

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3,4,5-Trimethoxytoluene Chemical Properties,Usage,Production

Chemical Properties

CLEAR YELLOW LIQUID

Uses

3,4,5-Trimethoxytoluene is a reagent for oxadiazolylindazole sodium channel modulators which are neuroprotective toward hippocampal neurons.

Uses

3,4,5-Trimethoxytoluene was used as a substructure model compound in the reaction of trimethoprim with free available chlorine (i.e. HOCl).

Definition

ChEBI: 3,4,5-Trimethoxytoluene is a member of methoxybenzenes.

Synthesis

86-81-7

6443-69-2

Using 3,4,5-trimethoxybenzaldehyde as the starting material, referring to the synthesis method of Example 2, 10 g of 3,4,5-trimethoxybenzaldehyde was dissolved in 100 g of tetrahydrofuran, 1 g of Catalyst B was added, and the hydrogenation reaction was carried out under hydrogen atmosphere. Upon completion of the reaction, the aldehyde group conversion was confirmed to be 100% by testing. The isolated yield of the target product 3,4,5-trimethoxytoluene was 96% based on the initial addition of 3,4,5-trimethoxybenzaldehyde.

References

[1] Bioorganic Chemistry, 2016, vol. 68, p. 214 - 218
[2] Tetrahedron, 2007, vol. 63, # 38, p. 9382 - 9386
[3] Synthesis, 1993, # 8, p. 797 - 802
[4] Synthetic Communications, 2006, vol. 36, # 14, p. 1961 - 1965
[5] Journal of Chemical Research, 2010, vol. 34, # 12, p. 717 - 718

3,4,5-Trimethoxytoluene Preparation Products And Raw materials

Raw materials

Preparation Products

Idebenone

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3,4,5-Trimethoxytoluene Suppliers

Belgium 1 Canada 2 China 264 Europe 2 Germany 4 India 17 Japan 5 Slovakia 1 South Korea 1 Switzerland 3 Ukraine 1 United Kingdom 16 United States 27 Global 344

J & K SCIENTIFIC LTD.

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Alfa Aesar

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TCI (Shanghai) Development Co., Ltd.

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Energy Chemical

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JinYan Chemicals(ShangHai) Co.,Ltd.

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Jia Xing Isenchem Co.,Ltd

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Adamas Reagent, Ltd.

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View Lastest Price from 3,4,5-Trimethoxytoluene manufacturers

Henan Fengda Chemical Co., Ltd

Product: 3,4,5-Trimethoxytoluene 6443-69-2
Price: US $100.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-25

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3,4,5-Trimethoxytoluene 6443-69-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3,4,5-Trimethoxytoluene 6443-69-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

6443-69-2, 3,4,5-TrimethoxytolueneRelated Search:

Benzotrifluoride Mesitylene (Trifluoromethoxy)benzene Trimethyl phosphite Trimethoxymethane Anisole 4-(Trifluoromethoxy)aniline 1,2,4-Trimethylbenzene Colchicine 3,4,5-Trimethoxyphenylacetic acid 3,4,5-Trimethoxyphenylacetonitrile 3,4,5-Trimethoxybenzoyl chloride 3,4,5-TRIMETHOXYCINNAMIC ACID 3,4,5-Trimethoxybenzonitrile 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID 3,4,5-Trimethoxybenzyl alcohol Methyl 3,4,5-trimethoxybenzoate 2,4,6-Trinitrotoluene

1,2,3-Trimethoxy-5-methylbenzene

5-Methyl-1,2,3-trimethoxybenzene

Benzene, 5-methyl-1,2,3-trimethoxy

Toluene, 3,4,5-trimethoxy-

5-METHYL PYROGALLOL TRIMETHYL ETHER

3,4,5-TRIMETHOXYTOLUENE

3,4,5-Trimethoxytolu

3,4,5-Trimethoxytolune

3,4,5-trimethoxytoluen

Benzene, 1,2,3-trimethoxy-5-methyl-

3,4,5-Trimethoxytoluene,97%

3-(3,4-dimethoxyphenyl)-2,3,4,6,7,8,9,9a-octahydro-1H-quinolizine hydrochloride

TriMethoxytoluene

3,4,5-Trimethoxytoluene ISO 9001：2015 REACH

3,4,5-Trimethoxytoluene 6443-69-2

Trimethoprim Lactnte

3,4,5-Trimethoxytoluene, ≥ 98.0%

1,2,3-Trimethoxy-5-methylbenzene - [T94157]

6443-69-2

Building Blocks

Organic Building Blocks

Ethers

Oxygen Compounds

Aromatic Hydrocarbons (substituted) & Derivatives

Anisoles, Alkyloxy Compounds & Phenylacetates