ChemicalBook > Product Catalog > Biochemical Engineering > Inhibitors > Neuronal Signaling > Opioid Receptor agonists > ADL-5859
ADL-5859
ADL-5859 Basic information
- Product Name:
- ADL-5859
- Synonyms:
-
- CS-24
- ADL 5859;ADL-5859
- ADL5859 HCl
- ADL5859 HCL;ADL5859; ADL 5859
- ADL-5859
- N,N-Diethyl-4-(5-hydroxyspiro[2H-1-benzopyran-2,4'-piperidin]-4-yl)benzamide hydrochloride
- ADL5859 hydrochloride
- Benzamide, N,N-diethyl-4-(5-hydroxyspiro[2H-1-benzopyran-2,4'-piperidin]-4-yl)-, hydrochloride (1:1)
- CAS:
- 850173-95-4
- MF:
- C24H29ClN2O3
- MW:
- 428.95166
- Product Categories:
-
- δ opioid receptor agonist.
- API
- Inhibitors
- Mol File:
- 850173-95-4.mol
More
Less
ADL-5859 Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- ≥21.45 mg/mL in DMSO; insoluble in EtOH; ≥5.48 mg/mL in H2O with ultrasonic
- form
- solid
- color
- White to off-white
More
Less
ADL-5859 Usage And Synthesis
Uses
N,?N-Diethyl-?4-?(5-?hydroxyspiro[2H-?1-?benzopyran-?2,?4''-?piperidin]?-?4-?yl)?-?benzamide Hydrochloride is a selective δ-opioid receptor agonist. It is an analgesic and antidepressive agent and a potential drug candidate for treating chronic pain.
in vivo
ADL-5859 (0.3-10 mg/kg; p.o. once) hydrochloride reverses hyperalgesia in inflamed paw of rats and shows robust antidepressant-like activity[1].
1.19Pharmacokinetic Properties of ADL-5859 in Rats and Dogs[1].| Rats IV 0.25 mg/kg and PO 3 mg/kg | Dogs IV 1 mg/kg and PO 3 mg/kg | |
| CLs (L/h/kg) | 1.8±0.5 | 0.4±0.1 |
| Vdss (L/kg) | 10.7±1.9 | 2.5±0.5 |
| t1/2 (oral, h) | 5.3±0.7 | 4.7±0.2 |
| F (%) | 33.4±3.2 | 66.5±6.8 |
| Animal Model: | Rats with Freund’s Complete Adjuvant (FCA) injection induced mechanical hyperalgesia[1] |
| Dosage: | 0.3-10 mg/kg |
| Administration: | Oral gavage; 0.3-10 mg/kg once |
| Result: | Produced 100% reversal of hyperalgesia in the inflamed paw with a dose of 3 mg/kg and showed an oral ED50 value of 1.4 mg/kg. |
| Animal Model: | Male Sprague-Dawley rats[1] |
| Dosage: | 0.3 and 3 mg/kg |
| Administration: | Oral gavage; 0.3 and 3 mg/kg once |
| Result: | Produced robust antidepressant-like activity in the rat forced swim assay with a dose of 3 mg/kg. |
target
δ-opioid receptor
IC 50
δ Opioid Receptor/DOR
ADL-5859Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
Chembest Research Laboratories Limited
- Tel
- +86-21-20908456
- sales@BioChemBest.com
VDM Biochemicals
- Tel
- 0330-2528181
- sales@vdmbio.com
BOC Sciences
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
Dalian Meilun Biotech Co., Ltd.
- Tel
- 0411-62910999 13889544652
- sales@meilune.com