2-NONENOIC ACID Chemical Properties

Melting point:

-9°C (estimate)

Boiling point:

130-132°C 2mm

Density 

0.93

refractive index 

1.4620

Flash point:

130-132°C/2mm

pka

4.82±0.10(Predicted)

form 

clear liquid

color 

Colorless to Almost colorless

Odor

at 100.00 %. fatty oily

Odor Type

fatty

JECFA Number

1380

BRN 

1721634

LogP

3.205 (est)

CAS DataBase Reference

3760-11-0(CAS DataBase Reference)

EPA Substance Registry System

2-Nonenoic acid (3760-11-0)

Safety Information

Risk Statements 

34

Safety Statements 

26-36/37/39

RIDADR 

3265

TSCA 

TSCA listed

HS Code 

2916.19.3000

HazardClass 

8

PackingGroup 

III

MSDS

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2-NONENOIC ACID Usage And Synthesis

Uses

2-Nonenoic Acid, a constituent of the volatile oil of Bupleurum chinense, exhibits antiinflammatory and fungicidal activity.

Definition

ChEBI: (E)-non-2-enoic acid is a monounsaturated fatty acid that is nonanoic acid which has undergone dehydrogenation to introduce a trans double bond at the 2-3 position. It is a medium-chain fatty acid, a monounsaturated fatty acid and an alpha,beta-unsaturated monocarboxylic acid. It is functionally related to an (E)-non-2-en-1-ol. It is a conjugate acid of an (E)-non-2-enoate.

Synthesis Reference(s)

Synthetic Communications, 8, p. 463, 1978 DOI: 10.1080/00397917808063573

Synthesis

In a 250mL three-necked flask equipped with a stirrer, thermometer and reflux condenser tube, 52g of malonic acid (0.5 mol), 73g of freshly distilled heptanal (0.6 mol, content 93.7%) were added, and 16mL of pyridine was added under stirring, and then heated with a water bath and stirred the reaction for 3 hrs at 70??C. Removing the water bath, it was heated with an electric heating jacket, and the reaction was continued under reflux for 3 hrs. The reaction was then heated with a water bath and stirred at 70?? for 3 h. The reaction was removed from the water bath and heated with an electric heating jacket, and the reaction was continued to stir under reflux for 3 h. After the reaction, when the reaction material was cooled to room temperature, it was transferred to 500mL dispensing funnel, acidified with 25% hydrochloric acid to pH1~2, to remove the pyridine, separated out the upper organic layer, dried with anhydrous magnesium sulfate, and then vacuum distilled, collected 110~144??/0.2kPa fractions, and obtained the crude product of trans-2-nonenoic acid, 78.1g, with the content of 82.9%, and the reaction yield was 83% according to the acrylic acid. The reaction yield was 83% according to acrylic acid. After fractionation of the crude product, the content of trans-2-nonenoic acid was 94.5%, and there was 3.5% trans-2-nonenoic acid.

2-NONENOIC ACID(3760-11-0)Related Product Information

• G-STROPHANTHIN
• DIGITOXIGENIN
• LANATOSIDE B
• Digitoxin
• CYMARIN
• LANATOSIDE A
• ETHYL TRANS-2-DECENOATE
• GITOXIGENIN
• DIGOXIN
• GITOXIN
• Methyl trans-2-nonenoate
• RUBRATOXIN B
• TRAUMATIC ACID
• 2-NONENOIC ACID
• CYTOCHALASIN A
• 1-NONENE
• TRANS-2-NONENE
• 2-TRIDECENOIC ACID