1-Chloro-4-(2-chloroethoxy)benzene Chemical Properties

Melting point:

39 °C

Boiling point:

184-186 °C(Press: 92 Torr)

Density 

1.246±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

CAS DataBase Reference

13001-28-0(CAS DataBase Reference)

EPA Substance Registry System

Benzene, 1-chloro-4-(2-chloroethoxy)- (13001-28-0)

1-Chloro-4-(2-chloroethoxy)benzene Usage And Synthesis

Synthesis

Example P1: Synthesis of 4-chloro-(2-chloroethoxy)-benzene 1. 1 g of tributylamine was added to the reactor as a catalyst, followed by the sequential addition of 26.4 g of 4-chlorophenol and 18.7 g of ethylene carbonate. 2. The reaction mixture was slowly heated to 150 °C and the reaction was maintained at this temperature for about 3 hours until the release of carbon dioxide gas ceased. 3. Upon completion of the reaction, the mixture was cooled to 85 °C and 1 g of dimethylformamide was added as a solvent. 4. 24 g of phosgene was passed into the reaction mixture in the form of a bulb at 85 °C. 5. The reaction temperature was maintained at 85 °C for 8 hours, after which the temperature was reduced to 60 °C. The reaction temperature was reduced to 60 °C. 6. 100 ml of water was added to quench the excess phosgene, followed by neutralization of the reaction mixture with 10.5 g of 25% aqueous sodium hydroxide. 7. The organic layer was separated and purified by reduced pressure distillation (150°-152 °C/40 mb) to give 36.0 g (93% yield) of the target product 4-chloro-(2-chloroethoxy)-benzene.

References

[1] Patent: US4959501, 1990, A
[2] Patent: US4806528, 1989, A

1-Chloro-4-(2-chloroethoxy)benzene(13001-28-0)Related Product Information

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• (S)-Amlodipine
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• Diphenyl chlorophosphate
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• Amlodipine Besylate
• Benzene
• 4-CHLOROPHENOXYACETYL CHLORIDE
• (2,4-DICHLORO-6-METHYL-PHENOXY)-ACETYL CHLORIDE
• 2-(2,6-DICHLOROPHENOXY)ACETYL CHLORIDE
• Difluorochloromethane
• 2-(4-CHLOROPHENOXY)-2-METHYLPROPANOYL CHLORIDE
• TRICHLOROACETIC ACID PENTACHLOROPHENYL ESTER
• 2-(4-CHLORO-2-METHYLPHENOXY)PROPIONYL CHLORIDE
• PENTACHLOROPHENYL DICHLOROACETATE
• 1-Chloro-4-(2-chloroethoxy)benzene
• 2,4,5-Trichlorophenyl chloroacetate