Basic information Uses Description Safety Supplier Related
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Methyl 2-phenylacetoacetate

Basic information Uses Description Safety Supplier Related

Methyl 2-phenylacetoacetate Basic information

Product Name:
Methyl 2-phenylacetoacetate
Synonyms:
  • Benzeneacetic acid,CAS:16648-44-5
  • BMK POWDER bmk white powder 3-Oxo-2-PhenylbutanaMide BMK
  • 16648-44-5 methyl α-acetylphenylacetate
  • BMK Glycidate powder 16648-44-5 manufacturer supplier suppliers factory
  • BMK Glycidate
  • Methyl 2-phenylacetoacetate
  • BMK Glycidate Methyl 2-phenylacetoacetate
  • BMK Benzeneacetic acidcas16648-44-5 white powder 3-Oxo-2-PhenylbutanaMide BMK
CAS:
16648-44-5
MF:
C11H12O3
MW:
192.21
EINECS:
234-232-0
Product Categories:
  • pharmaceutical intermediate
  • organic interme
  • intermediate
  • Additive
  • pharmaceutical
  • Intermediate
Mol File:
16648-44-5.mol
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Methyl 2-phenylacetoacetate Chemical Properties

Melting point:
58.5-59.0 °C
Boiling point:
92-96 °C(Press: 0.6 Torr)
Density 
1?+-.0.06 g/cm3(Predicted)
solubility 
DMF: 30 mg/ml; DMSO: 50 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 50 mg/ml; Methanol: 1 mg/ml
form 
A crystalline solid
pka
10.67±0.46(Predicted)
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Methyl 2-phenylacetoacetate Usage And Synthesis

Uses

Benzeneacetic acid, a-acetyl-, methyl ester can be used as a pharmaceutical raw material.

Description

Methyl 2-phenylacetoacetate is an analytical reference standard categorized as a precursor in the synthesis of amphetamines and methamphetamines. This product is intended for research and forensic applications.
The Drug Enforcement Administration is proposing the control of the chemical methyl alpha-phenylacetoacetate (also known as MAPA; methyl 3-oxo-2-phenylbutanoate; methyl 2-phenylacetoacetate; [alpha]-acetyl-benzeneacetic acid, methyl ester; and CAS Number: 16648-44-5) and its optical isomers as a list I chemical under the Controlled Substances Act (CSA). Methyl alpha-phenylacetoacetate is used in clandestine laboratories to illicitly manufacture the schedule II controlled substances phenylacetone (also known as phenyl-2-propanone or P2P), methamphetamine, and amphetamine and is important to the manufacture of these controlled substances.

Description

Methyl 2-phenylacetoacetate (Item No. 28352) is an analytical reference standard categorized as a precursor in the synthesis of amphetamines and methamphetamines. This product is intended for research and forensic applications.

Uses

D1, D2 dopamine receptor antagonist; butyrophenone antipsychotic and anti-emetic. Droperidol is a potent antagonist of dopamine subtype 2 receptor. It is an antipsychotic, which is used to treat acute behavioral anomalies. It helps to manage postoperative nausea and vomiting. Endogenous κ1b opioid receptor agonist.

Preparation

Methyl phenyldiazoacetate, precursor to cyclopropanation agents, is prepared by treating methyl phenylacetate with p-acetamidobenzenesulfonyl azide in the presence of base.

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