1,1,1-Trifluoroethyl-PEG3-Propargyl Chemical Properties

Boiling point:

243.5±35.0 °C(Predicted)

Density 

1.152±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

form 

Liquid

color 

Colorless to light yellow

1,1,1-Trifluoroethyl-PEG3-Propargyl Usage And Synthesis

Description

1,1,1-Trifluoroethyl-PEG3-Propargyl is a heterobifunctional reagent with an alkyne group and a trifluoroethyl group. The alkyne group reacts with azide compounds or biomolecules in copper catalyzed Click Chemistry to form a stable triazole linkage. The trifluoroethyl group is used to react with lysine and other primary amine groups in proteins, antibody and other molecules and surfaces.

Uses

1,1,1-Trifluoroethyl-PEG2-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. 1,1,1-Trifluoroethyl-PEG2-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

1,1,1-Trifluoroethyl-PEG3-Propargyl(1835759-73-3)Related Product Information

• 1,1,1-Trifluoroethyl-PEG4-azide
• 1,1,1-Trifluoroethyl-PEG5-Alcohol
• 1,1,1-Trifluoroethyl-PEG4-Aminooxy
• 1,1,1-Trifluoroethyl-PEG2-azide
• 1,1,1-Trifluoroethyl-PEG4-amine
• 1,1,1-Trifluoroethyl-PEG5-Propargyl