1,1,1-Trifluoroethyl-PEG2-azide Chemical Properties

storage temp. 

Storage temp. 2-8°C

form 

Liquid

color 

Colorless to light yellow

1,1,1-Trifluoroethyl-PEG2-azide Usage And Synthesis

Description

1,1,1-Trifluoroethyl-PEG2-azide is a crosslinker containing an azide group and a trifluroethyl group. The azide group can participate in Click Chemistry reactions with reagents such as alkynes, DBCO and BCN. The hydrophilic PEG spacer increases solubility in aqueous media. The trifluoroethyl group is used to react with lysine and other primary amine groups in proteins, antibody and other molecules and surfaces.

Uses

1,1,1-Trifluoroethyl-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. 1,1,1-Trifluoroethyl-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

1,1,1-Trifluoroethyl-PEG2-azide(1835759-68-6)Related Product Information

• 1,1,1-Trifluoroethyl-PEG3-Propargyl
• 1,1,1-Trifluoroethyl-PEG4-azide
• 1,1,1-Trifluoroethyl-PEG5-Alcohol
• 1,1,1-Trifluoroethyl-PEG4-Aminooxy
• 1,1,1-Trifluoroethyl-PEG4-amine
• 1,1,1-Trifluoroethyl-PEG5-Propargyl