1,1,1-Trifluoroethyl-PEG5-Propargyl Chemical Properties

Boiling point:

353.9±37.0 °C(Predicted)

Density 

1.142±0.06 g/cm3(Predicted)

1,1,1-Trifluoroethyl-PEG5-Propargyl Usage And Synthesis

Description

1,1,1-Trifluoroethyl-PEG5-Propargyl forms triazole linkage with azides via copper catalyzed azide-alkyne Click Chemistry. The trifluoroethyl group is reactive towards primary amine groups in proteins, antibody and other molecules and surfaces.

Uses

1,1,1-Trifluoroethyl-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. 1,1,1-Trifluoroethyl-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

1,1,1-Trifluoroethyl-PEG5-Propargyl(1817735-37-7)Related Product Information

• 1,1,1-Trifluoroethyl-PEG3-Propargyl
• 1,1,1-Trifluoroethyl-PEG4-azide
• 1,1,1-Trifluoroethyl-PEG5-Alcohol
• 1,1,1-Trifluoroethyl-PEG4-Aminooxy
• 1,1,1-Trifluoroethyl-PEG2-azide
• 1,1,1-Trifluoroethyl-PEG4-amine