Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Chemical Reagents >  Organic reagents >  aliphatic ketones >  1,3-Cyclohexanedione

1,3-Cyclohexanedione

Basic information Safety Supplier Related

1,3-Cyclohexanedione Basic information

Product Name:
1,3-Cyclohexanedione
Synonyms:
  • Dihydro-1,3-benzenediol
  • NSC 57477
  • 1,3-Cyclohexanedione, 97% 500GR
  • 1,3-Cyclohexanedione 97%
  • 1,3-Cyclohexanedione SynonyMs Cyclohexane-1,3-dione
  • 1,3-Cyclohexanedione, 97+%, may cont. up to 1% NaCl
  • 1,3-Cyclohexanedione [for HPLC Labeling]
  • 1,3-Diketocyclohexane
CAS:
504-02-9
MF:
C6H8O2
MW:
112.13
EINECS:
207-980-0
Product Categories:
  • ketone
  • Intermediates
  • Analytical Chemistry
  • Carbonyl Group Labeling Reagents for Fluorescence HPLC
  • Fluorescence Detection (HPLC Labeling Reagents)
  • Isotope Labelled Compounds
  • cyclic compounds
  • HPLC Labeling Reagents
  • bc0001
  • Amidite
Mol File:
504-02-9.mol
More
Less

1,3-Cyclohexanedione Chemical Properties

Melting point:
101-105 °C (lit.)
Boiling point:
170.05°C (rough estimate)
Density 
1,1 g/cm3
vapor pressure 
0.018Pa at 25℃
refractive index 
1.4576 (estimate)
storage temp. 
Store at +2°C to +8°C.
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Powder
pka
5.26(at 25℃)
color 
Pale yellow to beige
Water Solubility 
soluble
Merck 
14,3178
BRN 
385888
LogP
0.461 at 21.4℃ and pH3.2
Surface tension
69.9mN/m at 1.01g/L and 22℃
CAS DataBase Reference
504-02-9(CAS DataBase Reference)
NIST Chemistry Reference
1,3-Cyclohexanedione(504-02-9)
EPA Substance Registry System
1,3-Cyclohexanedione (504-02-9)
More
Less

Safety Information

Safety Statements 
24/25
WGK Germany 
3
RTECS 
GV0350000
8-21
TSCA 
Yes
HS Code 
29142900

MSDS

More
Less

1,3-Cyclohexanedione Usage And Synthesis

Chemical Properties

pale yellow to beige powder

Uses

1,3-Cyclohexanedione is used in organic synthesis and pharmaceutical intermediates. It is the intermediate of herbicides sulcotrione and nitrosulfonone. It is also nitisinone intermediate.

Uses

1,3-Cyclohexanedione can be used as a building block in the synthesis of:

  • 9-substituted 1,8-dioxo-xanthenes by reacting with unactivated aldehydes via aldol condensation/ Michael addition reaction.
  • [(1,2,3-triazol-4-yl)methoxy-phenyl]-2H-indazolo[2,1-b]phthalazine-trione derivatives by treating with phthalhydrazide, aromatic propargyloxy aldehydes, and azides via a four-component condensation reaction.
It can be also used to prepare 2-substituted adducts, which are important intermediates for the synthesis of ?-enaminones , polyhydroquinoline derivatives , 1,8-dioxo-dodecahydroxanthenes , spirocyclopentanols , oxathioles , and triquinanes.

Definition

ChEBI: 1,3-Cyclohexanedione is a cyclohexanedione carrying oxo substituents at positions 1 and 3. It is a beta-diketone and a cyclohexanedione.

Synthesis Reference(s)

The Journal of Organic Chemistry, 30, p. 3206, 1965 DOI: 10.1021/jo01020a506

Purification Methods

Crystallise the dione from *benzene. Dissolve ~50g of the diol in 140mL of *C6H6 under N2, cool, collect the solid and dry it in a vacuum desiccator overnight. It is unstable and should be stored under N2 or Ar at ~0o. [Thompson Org Synth Coll Vol III 278 1955, Beilstein 7 IV 1985.]

1,3-CyclohexanedioneSupplier

Xuzhou datang chemical co. LTD Gold
Tel
0516-88955777 15952285777
Email
120958853@qq.com
Wuhan Hongde Yuexin Pharmaceutical Technology Co., Lt Gold
Tel
027-83855392 15827396479
Email
wuhanfudechem03@sina.com
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. Gold
Tel
133-96369453 18678026865
Email
sdfantai@163.com
Weifang Weimeng Chemical Co., Ltd. Gold
Tel
0536-8790166 15105445095
Email
weimengchem@163.com
Shanghai Taijilin Industrial Co., Ltd. Gold
Tel
021-50630626 18964684208
Email
kate@tajilin.com