t-Boc-Aminooxy-PEG4-CH2CO2H
t-Boc-Aminooxy-PEG4-CH2CO2H Basic information
- Product Name:
- t-Boc-Aminooxy-PEG4-CH2CO2H
- Synonyms:
-
- t-Boc-Aminooxy-PEG4-CH2CO2H
- 3,6,9,12,15-Pentaoxa-2-azaheptadecanedioic acid, 1-(1,1-dimethylethyl) ester
- t-Boc-Aminooxy-PEG4-CH2CO2H boc
- N-Boc-Aminooxy-PEG4-CH2COOH
- t-Boc-Aminooxy-PEG4-CH2COOH
- CAS:
- 2028281-90-3
- MF:
- C15H29NO9
- MW:
- 367.39
- Mol File:
- 2028281-90-3.mol
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t-Boc-Aminooxy-PEG4-CH2CO2H Chemical Properties
- Density
- 1.166±0.06 g/cm3(Predicted)
- pka
- 3.39±0.10(Predicted)
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t-Boc-Aminooxy-PEG4-CH2CO2H Usage And Synthesis
Description
t-Boc-Aminooxy-PEG4-CH2CO2H is a crosslinking reagent with a Boc-protected aminooxy group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU). The Boc-protected amine can be deprotected under mild acidic conditions. PEG4 spacer increases solubility in aqueous media.
Uses
Boc-Aminooxy-PEG4-CH2CO2H is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
Alkyl/ether; PEGs
References
[1] Zhao B, et al. Protein Engineering in the Ubiquitin System: Tools for Discovery and Beyond. Pharmacol Rev. 2020 Apr;72(2):380-413. DOI:10.1124/pr.118.015651
t-Boc-Aminooxy-PEG4-CH2CO2HSupplier
Jinan elephant international trading co., LTD
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- 13006575422@163.com
Beijing Jin Ming Biotechnology Co., Ltd.
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- 010-60605840 18892239720
- psaitong@jm-bio.com
Amatek Scientific Co. Ltd.
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- 0512-56316828
- info@amateksci.com
TargetMol Chemicals Inc.
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- +1-781-999-5354; +17819995354
- marketing@targetmol.com
Shaanxi Xinyan Bomei Biotechnology Co., Ltd.
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- 13892832556
- 2440688701@qq.com