13,14-DIHYDRO-15-KETO PROSTAGLANDIN E2 Chemical Properties

Boiling point:

538.1±45.0 °C(Predicted)

Density 

1.086±0.06 g/cm3(Predicted)

storage temp. 

−20°C

pka

4.75±0.10(Predicted)

Safety Information

Hazard Codes 

F,Xn,Xi

Risk Statements 

11-20/21/22-36/37/38-67-66-36

Safety Statements 

16-26-36

RIDADR 

UN 1231 3/PG 2

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

13,14-DIHYDRO-15-KETO PROSTAGLANDIN E2 Usage And Synthesis

Description

13,14-dihydro-15-keto Prostaglandin E₂ (13,14-dihydro-15-keto PGE₂) is a metabolite of PGE₂ and the primary PGE₂ metabolite in plasma. It is formed from PGE₂ via a 15-keto PGE₂ intermediate by 15-oxo-PG Δ¹³ reductase. Unlike PGE₂, 13,14-dihydro-15-keto PGE₂ does not bind effectively to the PGE₂ receptors EP₂ and EP₄ expressed in CHO cells (K_is = 12 and 57 μM, respectively) or induce adenylate cyclase activity in the same cells (EC₅₀s = >18 and >38 μM, respectively). Levels of 13,14-dihydro-15-keto PGE₂ are increased in the plasma of women in the third trimester of pregnancy and in women during and immediately after labor and delivery. Levels of 13,14-dihydro-15-keto PGE₂ levels are decreased in tumor tissue compared to adjacent non-cancerous tissue isolated from patients with non-small cell lung cancer (NSCLC).

Uses

13,14-Dihydro-15-ketoPGE2 is a primary metabolite of PGE2 in plasma.

Definition

ChEBI: The 13,14-dihydro derivative of 15-oxo-prostaglandin E2.

13,14-DIHYDRO-15-KETO PROSTAGLANDIN E2(363-23-5)Related Product Information

• rHuGlucagon
• Recombinant Human Stem Cell Factor, Sf9
• HEPATITIS B SURFACE ANTIGEN, RECOMBINANT
• DEFEROXAMINE MESYLATE
• Bromocriptine mesylate
• D-Luciferin potassium salt
• Recombinant Streptavidin
• Epidermal Growth Factor
• (3aS*,4R*,9bR*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta[c]quinoline
• rrVEGF
• RECOMBINANT HUMAN PROCALCITONIN
• PHORBOL 12-MYRISTATE 13-ACETATE
• Human alpha Fetoprotein
• Oxytocin
• HUPTH
• cis-5-Eicosenoic acid
• 13,14-DIHYDRO-15-KETO PROSTAGLANDIN E2
• 15-KETO PROSTAGLANDIN E2