Boc-5-aminopentanoic acid Chemical Properties

Melting point:

48-52 °C(lit.)

Boiling point:

160-168 °C0.8 mm Hg(lit.)

Density 

1.1518 (rough estimate)

refractive index 

1.4500 (estimate)

Flash point:

>230 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

soluble in Methanol

form 

Powder

pka

4.72±0.10(Predicted)

color 

Off-white

BRN 

2048862

CAS DataBase Reference

27219-07-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

F 

10-21

HazardClass 

IRRITANT

HS Code 

29241990

MSDS

• Language:English Provider:SigmaAldrich

Boc-5-aminopentanoic acid Usage And Synthesis

Description

Boc-5-aminopentanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. Boc-5-aminopentanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Chemical Properties

solid

Uses

Boc-5-aminovaleric acid can be used to synthesize inhibitors of bacterial quorum seining and biofilm formation. It can also be used to synthesize diblock and triblock copolymers.

Synthesis Reference(s)

The Journal of Organic Chemistry, 48, p. 2424, 1983 DOI: 10.1021/jo00162a028

Boc-5-aminopentanoic acid(27219-07-4)Related Product Information

• Ethyl 2-(Chlorosulfonyl)acetate
• Folic acid
• Glycine
• ALTRENOGEST
• 5-AMINOVALERIC ACID
• MAGNESIUM DIPROPYLACETATE HYDRATE
• Estradiol valerate
• 2-Propylpentanoic acid
• Pivalic acid
• N-Carbobenzyloxyglycine
• 1-(Boc-amino)cyclopropanecarboxylic acid
• BOC-HYP(BZL)-OH
• BOC-L-2-AMINOADIPIC ACID
• Boc-Hyp-OH
• (3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid
• BOC-L-Proline
• N-Boc-trans-4-Hydroxy-L-proline methyl ester
• Fmoc-Orn(Boc)-OH