ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER
ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER Basic information
- Product Name:
- ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER
- Synonyms:
-
- Methyl acetobromo-α-D-glucuronate, Bromo-2,3,4-tri-O-acetyl-α-D-glucopyranuronic acid methyl ester, (2,3,4-Tri-O-acetyl-α-D-glucopyranosyl bromide)uronic acid methyl ester
- 1-Bromo-1-deoxy-2-O,3-O,4-O-triacetyl-α-D-glucopyranuronic acid methyl ester
- 2,3,4-Trideoxy-2,3,4-triacetoxy-1-bromo-1-deoxy-α-D-glucopyranuronic acid methyl ester
- 2-O,3-O,4-O-Triacetyl-1-bromo-1-deoxy-α-D-glucopyranuronic acid methyl ester
- 2-O,3-O,4-O-Triacetyl-6-O-methyl-6-C-oxo-1-bromo-1-deoxy-α-D-glucopyranose
- 2-O,3-O,4-O-Triacetyl-6-O-methyl-6-oxo-α-D-glucopyranosyl bromide
- 6-O-Methyl-2-O,3-O,4-O-triacetyl-α-D-glucopyranuronosyl bromide
- Einecs 244-203-4
- CAS:
- 21085-72-3
- MF:
- C13H17BrO9
- MW:
- 397.17
- EINECS:
- 244-203-4
- Product Categories:
-
- carbohydrate
- 13C & 2H Sugars
- Carbohydrates & Derivatives
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 21085-72-3.mol
ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER Chemical Properties
- Melting point:
- 80-110 °C(lit.)
- Boiling point:
- 388.6±42.0 °C(Predicted)
- Density
- 1.52
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Acetonitrile (Slightly), Chloroform (Slightly, Heated, Sonicated), Dichlorometha
- form
- Crystalline Powder or Solid
- color
- White to gray
- BRN
- 96281
- Stability:
- Moisture and Temperature Sensitive
- InChIKey
- BCDVKFMSIQGEHB-CIQUZCHMSA-N
- CAS DataBase Reference
- 21085-72-3(CAS DataBase Reference)
MSDS
- Language:English Provider:SigmaAldrich
ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER Usage And Synthesis
Uses
Acetobromo-α-D-glucuronic acid methyl ester is used for the synthesis of HMR1098-S-glucuronide methyl ester, a new K-ATP-blocking agent being developed as a drug for prevention of sudden cardiac death.
Acetobromo-α-D-glucuronic acid methyl ester is used for the synthesis of water-soluble glucuronide derivatives of Camptothecin, which is used for cancer prodrug monotherapy and antibody-directed enzyme prodrug therapy (ADEPT).
Acetobromo-α-D-glucuronic acid methyl ester is used for the synthesis of glucuronide prodrug compounds of Janus kinase (JAK) inhibitor tofacitinib, which could be cleaved by β-glucuronidase enzymes such as those produced by the microbiome in the gastrointestinal tract, thereby increasing levels of tofacitinib at the site of gastrointestinal inflammation and limiting the systemic exposure of tofacitinib when treating localized inflammatory diseases.
Chemical Properties
White Crystalline Solid
Uses
Antitumor agent
ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTERSupplier
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ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER(21085-72-3)Related Product Information
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- Ethyl glyoxalate
- 2-[(Acetyloxy)methoxy]ethyl acetate
- Pinacol vinylboronate
- 2,3,4,6-Tetra-O-acetyl-alpha-D-glucopyranosyl bromide
- 2-Bromoethyl acetate
- 2-(2-Methoxyethoxy)acetic acid
- 5-Bromopentan-1-ol
- 1-Bromo-4-methoxybutane
- 1-BROMO-2-BUTANOL
- 6-Bromo-1-hexanol
- 6-Bromohexanoic acid
- 3-BROMO-1,2-PROPANEDIOL
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- D-Glucuronic acid