4-CHLORO-2-ANISIDINE HYDROCHLORIDE Chemical Properties

Melting point:

52°C

Boiling point:

260°C (rough estimate)

Density 

1.1760 (rough estimate)

refractive index 

1.5430 (estimate)

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

solubility 

Chloroform (Slightly), Methanol (Slightly)

pka

3.90±0.10(Predicted)

form 

Solid

color 

Dark Brown

CAS DataBase Reference

93-50-5(CAS DataBase Reference)

EPA Substance Registry System

Benzenamine, 4-chloro-2-methoxy- (93-50-5)

Safety Information

Hazard Codes 

Xi

Risk Statements 

43

Safety Statements 

36/37

Hazard Note 

Irritant/Keep Cold

TSCA 

TSCA listed

HS Code 

2921420090

4-CHLORO-2-ANISIDINE HYDROCHLORIDE Usage And Synthesis

Chemical Properties

Dark Brown Low Melting Solid

Uses

4-Chloro-2-methoxyaniline is an important intermediate used for the synthesis of CXCR2 antagonists and some CD4-gp120 binding inhibitors.

Synthesis

General procedure: Make a suspension of iron powder (5.0 eq.), ammonium chloride (0.65 eq.) and distilled water and reflux for 15 minutes. 2-Nitro-5-chloroanisole (1.0 eq.) was added slowly and the reaction mixture continued to be stirred under reflux conditions. The progress of the reaction was monitored by thin layer chromatography (TLC) and when the reaction was complete, the reaction mixture was neutralized by slow dropwise addition of 5% aqueous sodium bicarbonate, followed by filtration through diatomaceous earth. The filtrate was extracted three times with ethyl acetate. The organic phases were combined and washed once each with saturated saline and 5% aqueous hydrochloric acid, in that order. The aqueous phases were combined, the pH was adjusted to neutral with 20% aqueous sodium hydroxide, and then extracted three times with ethyl acetate. The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The product can be purified by mixed solvent column chromatography with ethyl acetate/hexane or used directly as a crude product. Product purity was confirmed by 1H-NMR. Example 1: The crude 4-chloro-2-methoxyaniline was obtained as a dark purple oil (1.15 g, 91% yield) from the reaction of iron powder (2.23 g, 40 mmol), ammonium chloride (278 mg, 5.2 mmol), water (48 mL), and 5-chloro-2-nitroanisole (1.5 g, 8.0 mmol) for 1.5 h. The reaction was carried out by 1H NMR ( 300MHz, CDCl3): δ 6.78 (m, 2H), 6.65 (d, 1H), 3.86 (s, 3H). Example 2: 4-Chloro-2-methoxyaniline crude was obtained as a dark purple oil (2.35 g, 93% yield) after reacting for 2 hours with iron powder (4.47 g, 80.0 mmol), ammonium chloride (556 mg, 10.4 mmol), water (80 mL) and 5-chloro-2-nitroanisole (3.0 g, 16.0 mmol). No 1H-NMR analysis was performed.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 14, p. 3864 - 3867
[2] ChemMedChem, 2014, vol. 9, # 5, p. 962 - 972
[3] Patent: WO2006/71730, 2006, A1. Location in patent: Page/Page column 79; 80
[4] Patent: WO2014/28805, 2014, A1. Location in patent: Page/Page column 65
[5] Patent: WO2004/37789, 2004, A2. Location in patent: Page 312

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