BENZYL GLYCOLATE Chemical Properties

Boiling point:

136 °C/14 mmHg (lit.)

Density 

1.171 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.527(lit.)

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Sparingly), Methanol (Slightly)

form 

Oil

pka

12.96±0.10(Predicted)

color 

Colourless

InChI

InChI=1S/C9H10O3/c10-6-9(11)12-7-8-4-2-1-3-5-8/h1-5,10H,6-7H2

InChIKey

VPYJBEIOKFRWQZ-UHFFFAOYSA-N

SMILES

C(OCC1=CC=CC=C1)(=O)CO

Safety Information

WGK Germany 

3

HS Code 

2918199890

Storage Class

10 - Combustible liquids

MSDS

• Language:English Provider:SigmaAldrich

BENZYL GLYCOLATE Usage And Synthesis

Uses

Benzyl Glycolate was utilized as a potential moiety for the preparation of phosphonate dipeptides as potential inhibitors of VanX.

Uses

Benzyl glycolate may be used for the synthesis of the methyl [2-(2′-benzyloxy-2′-oxoethyl)-5-acetamido-4,7,8,9- tetra-O-acetyl-3,5-dideoxy-α- and -β-D-glycero-D-galacto-2-nonulopyranosid]onate. It may be used for the preparation of monosaccharide building blocks. It may also be used for the synthesis of the following new polymeric phosphazenes having pendent esters of glycolic or lactic acid as side units:

• poly[bis(ethyl glycolato)phosphazene]
• poly[bis(ethyl lactato)phosphazene]
• poly[bis(benzyl glycolato)phosphazene]
• poly[bis(benzyl lactato)phosphazene]

General Description

Benzyl glycolate is a benzyl ester of glycolic acid.

Synthesis

The general procedure for the synthesis of phenylmethyl ethanoate from ethanoic acid and benzyl bromide was as follows: first, a suspension formed by 2-hydroxyacetic acid (70% aqueous solution, 889 mg, 12.0 mmol) and Cs2CO3 (1955 mg, 6.00 mmol) in a solvent mixture of methanol (22 mL) and water (4 mL) was stirred for 30 min at room temperature. Subsequently, the solvent was removed and the residue was dissolved in DMF (18 mL) pre-cooled to 0 °C. After 10 min, benzyl bromide (2155 mg, 12.6 mmol) was added and the reaction mixture was continued to be stirred for 24 h at room temperature. Upon completion of the reaction, the reaction was quenched with brine (20 mL) and the organic layer was extracted with ethyl acetate (3 x 25 mL). The extract was washed sequentially with water (25 mL) and brine (20 mL), dried over MgSO4 and concentrated in vacuum to afford 1877 mg (97% yield) of benzyl 2-hydroxyacetate as a colorless liquid.HPLC analysis showed a retention time of 2.68 min (70%).

References

[1] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 16, p. 4903 - 4909
[2] Journal of Organic Chemistry, 2000, vol. 65, # 22, p. 7667 - 7675
[3] Patent: US2016/340365, 2016, A1. Location in patent: Paragraph 0126; 0127
[4] Patent: US2016/297784, 2016, A1. Location in patent: Paragraph 0150; 0151
[5] Journal of the American Chemical Society, 2010, vol. 132, # 31, p. 10920 - 10934

BENZYL GLYCOLATE(30379-58-9)Related Product Information

• Dimethyl oxalate
• Sodium glycolate
• Methyl glycolate
• Ethylene carbonate
• Ethyl glycolate
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