4-Methylpyridazine Chemical Properties

Boiling point:

98-100 °C/11 mmHg (lit.)

Density 

1.06 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.521(lit.)

Flash point:

222 °F

storage temp. 

Sealed in dry,Room Temperature

pka

3.74±0.10(Predicted)

form 

Liquid

color 

Clear yellow

Specific Gravity

1.060

λmax

292nm(H2O)(lit.)

BRN 

105689

InChI

InChI=1S/C5H6N2/c1-5-2-3-6-7-4-5/h2-4H,1H3

InChIKey

AIKUBOPKWKZULG-UHFFFAOYSA-N

SMILES

C1=NN=CC=C1C

CAS DataBase Reference

1120-88-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39-36

WGK Germany 

3

HS Code 

29339900

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4-Methylpyridazine Usage And Synthesis

Chemical Properties

Clear yellow liquid

Uses

4-Methylpyridazine was used in the preparation of series of novel pyridazine derivatives structurally related to bipyridine cardiotonics.

Reactions

4-methylpyridazine could be used as a starting material to synthesize a series of novel pyridazine derivatives structurally related to bipyridine cardiotonics[1].
Pyridazine (pydz) and 4-methylpyridazine (4Me-pydz) could form stable bis(monodentate) complexes of general formulae fac-[PtXMe3L2](X = Cl, Br or I) and fac-[ReX(CO)3L2](X = Cl, Br or I). These complexes in above-ambient temperature solutions exhibit 1,2-fluxional shifts between the nitrogen donor pairs of each ring[2].

General Description

Products of reaction of methyl iodide with 4-methylpyridazine has been investigated by NMR spectra. Solvent free oxidation of 4-methylpyridazine by acetyl peroxyborate, peracetic acid and hydrogen peroxide has been reported.

References

[1] Haider N, et al. Pyridazine analogues of biologically active compounds. Part 5: Novel potential cardiotonics of the amrinone type. Organic Electronics, 1989.
[2] Abel E, et al. 1,2-Metallotropic shifts in trimethylplatinum(IV) and tricarbonylrhenium(I) halide complexes of pyridazine and 4-methylpyridazine. Journal of the Chemical Society, Dalton Transactions, 1994; 445-455.

4-Methylpyridazine(1120-88-3)Related Product Information

• Hydralazine
• Sulfachloropyridazine sodium
• Thioridazine
• 4-Methyl-2-pentanone
• Tetramethylpyrazine
• 3,6-Dihydroxy-4,5-dimethylpyridazine
• 3,6-Dichloropyridazine-4-carboxylic acid
• 4-Pyridazinecarboxylic acid
• 3,6-DICHLORO-4-METHYLPYRIDAZINE,3,6-Dichloro-5-methylpyridazine
• MINAPRINE DIHYDROCHLORIDE
• 4-METHYLPYRIDAZINE-3,6-DIOL,3,6-DIHYDROXY-4-METHYLPYRIDAZINE,3,6-DIHYDROXY-4-METHYLPYRIDAZINE (4-METHYLMALEIC HYDRAZIDE)
• 3,6-Dichloro-4,5-dimethylpyridazine
• 4,5-Dihydro-6-methylpyridazin-3(2H)-one
• 4-Methylpyridazine-3-carboxylicacid
• 4,5-Dimethylpyridazine-3,6-diol
• 5-METHYLPYRIDAZIN-3-AMINE
• 3-METHYLPYRIDAZINE
• 3-AMINO-6-METHYLPYRIDAZINE