3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone Chemical Properties

Melting point:

190-200°C

Boiling point:

748.9±60.0 °C(Predicted)

Density 

1.177

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

solubility 

Chloroform, Ethyl Acetate, Methanol

form 

Solid

pka

3.55±0.50(Predicted)

color 

White to Off-White

LogP

10.28 at 21℃

3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone Usage And Synthesis

Chemical Properties

Off-white Solid

Uses

(4R)-3-[(2S,5R)-5-(4-Fluorophenyl)-2-[(R)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-2-oxazolidinone is an intermediate in the preparat ion of Ezetimibe (E975000).

Uses

(4S3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-2-oxazolidinone is used in the synthesis of Ezetimibe (E975000), an antihyperlipoproteinemic; a cholesterol absorption inhibitor.

3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone(272778-12-8)Related Product Information

• ALTRENOGEST
• Acetaminophen
• Lithium bis(trimethylsilyl)amide
• Glycine
• N,N-Dimethyl-1,4-phenylenediamine
• EC 2.6.1.2
• Trimethylphenylammonium chloride
• Betaine
• Dichloromethylphenylsilane
• Methyltriphenylphosphonium bromide
• Tris(hydroxymethyl)aminomethane
• 3-[5-(1,5-Dioxo-5-(p-fluophenylpentyl]-4R-phenyl-2-oxazolidinone
• EzetiMibe LactaM Cleaved Alcohol
• Ezetimibe
• 1,5-Pentanedione, 1,5-bis(4-fluorophenyl)-
• 5-(4-FLUOROPHENYL)VALERIC ACID
• ent-EzetiMibe
• EzetiMibe (3R,4R,3'S)-IsoMer