Basic information Safety Supplier Related

L-838417

Basic information Safety Supplier Related

L-838417 Basic information

Product Name:
L-838417
Synonyms:
  • 3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4,-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-β]pyridazine
  • 7-(tert-Butyl)-3-(2,5-difluorophenyl)-6-((1-methyl-1H-1,2,4-triazol-5-yl)methoxy)-[1,2,4]triazolo[4,3-b]pyridazine
  • 1,2,4-Triazolo[4,3-b]pyridazine,3-(2,5-difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-
  • L-838417
  • 3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4,-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine
  • 5-({[7-tert-butyl-3-(2,5-difluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]oxy}methyl)-1-methyl-1,2,4-triazole
  • L-838417_x000b_
CAS:
286456-42-6
MF:
C19H19F2N7O
MW:
399.4
Product Categories:
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Heterocyclic Compounds
  • Pharmaceuticals
Mol File:
286456-42-6.mol
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L-838417 Chemical Properties

Melting point:
196-198°C
Density 
1.40±0.1 g/cm3(Predicted)
storage temp. 
Store at +4°C
solubility 
DMSO: ≥20mg/mL
pka
2.13±0.10(Predicted)
form 
powder
color 
white to off-white
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Safety Information

WGK Germany 
3
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L-838417 Usage And Synthesis

Chemical Properties

White to Off-White Solid

Uses

A selective ligand for GABAA receptors

Uses

L-838417 is an anxiolytic agent and a selective GABAA receptor partial agonist that selectively binds to α1, α2, α3 and α5 subunits (1,2). It also exhibits antinociceptive and anti-inflammatory properties.

Biological Activity

Subtype-selective GABA A receptor partial agonist. Selectively binds to α 1, α 2, α 3 and α 5 subunits (K i values are 0.79, 0.67, 0.67 and 2.25 nM respectively) but displays no efficacy at α 1 ( α 1-sparing). Exhibits non-sedative anxiolytic, antinociceptive and anti-inflammatory activity in vivo .

storage

Store at +4°C

L-838417 Supplier

J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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jkinfo@jkchemical.com
3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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3bsc@sina.com
Chemsky(shanghai)International Co.,Ltd.
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021-50135380
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shchemsky@sina.com
BOC Sciences
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1-631-485-4226; 16314854226
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info@bocsci.com
EMMX Biotechnology LLC
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888-539-0666
Email
info@emmx.com