SL0101 Chemical Properties

Melting point:

128-132°C

Boiling point:

753.0±60.0 °C(Predicted)

Density 

1.57±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Acetone (Slightly), Methanol (Slightly)

form 

Yellow solid

pka

6.20±0.40(Predicted)

color 

Pale Yellow to Brown

InChIKey

SXOZSDJHGMAEGZ-IGKKHSBFSA-N

SMILES

O1[C@H]([C@@H]([C@@H]([C@H]([C@@H]1C)OC(=O)C)OC(=O)C)O)Oc2[c](c3c([o]c2c4ccc(cc4)O)cc(cc3O)O)=O

Safety Information

WGK Germany 

WGK 1

HS Code 

2940000080

Storage Class

11 - Combustible Solids

SL0101 Usage And Synthesis

Description

The p90 ribosomal S6 kinases (RSK) 1-4 are downstream members of the extracellular signal-regulated kinase (ERK)/MAPK cascade. SL 0101-1 is a kaempferol glycoside, isolated from the tropical plant F. refracta, that selectively inhibits RSK2 with an IC₅₀ value of 89 nM (K_i = 1 μM) without interfering with upstream activators of RSK, including ERK, MEK, EGFR, and PKC. At 100 μM, SL 0101-1 inhibits the proliferation of MCF-7 breast cancer cells, arresting cells in the G₁ phase of the cell cycle. SL 0101-1 has been used to characterize the intracellular signaling events associated with angiotensin II-induced tyrosine kinase activation with a concentration of 30 μM attenuating angiotensin II-induced cell proliferation.

Chemical Properties

Tan Solid

Uses

SL 0101 is a potent and selective inhibitor of p90 Rsk, without inhibiting the function of upstream kinases such as MEK, Raf, or PKC.

Biological Activity

Selective inhibitor of p90 ribosomal S6 kinase (RSK) (IC 50 = 89 nM for RSK2). Does not inhibit upstream kinases such as MEK, Raf and PKC. Inhibits the growth of MCF-7 human breast cancer cells with no effect on the normal breast cell line.

storage

-20°C

References

[1] JEFFREY A. SMITH. Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation.[J]. Cancer research, 2005, 146 1: 1027-1034. DOI: 10.1158/0008-5472.1027.65.3
[2] MICHAEL D GODENY  Peter P S. ERK1/2 regulates ANG II-dependent cell proliferation via cytoplasmic activation of RSK2 and nuclear activation of elk1.[J]. American journal of physiology. Cell physiology, 2006, 291 6: C1308-17. DOI: 10.1152/ajpcell.00618.2005

SL0101(77307-50-7)Related Product Information

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• SL0101