Linarin
Linarin Basic information
- Product Name:
- Linarin
- Synonyms:
-
- LINARIN
- BUDDLEOSIDE
- BUDDLOSIDE
- ACACETIN-7-O-RUTINOSIDE
- ACACETIN-7-RUTINOSIDE
- 7-[[6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-5-hydroxy-4'-methoxyflavone
- 7-[[6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-methoxyphenyl)-4H-benzopyran-4-one
- 7-((6-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-5-hydroxy-2-(4-methoxyphenyl)-4H-benzopyran-4-one
- CAS:
- 480-36-4
- MF:
- C28H32O14
- MW:
- 592.55
- EINECS:
- 207-547-6
- Product Categories:
-
- Tri-substituted Flavones
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Mol File:
- 480-36-4.mol
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Linarin Chemical Properties
- Melting point:
- 258-260°C
- Boiling point:
- 885.2±65.0 °C(Predicted)
- Density
- 1.62±0.1 g/cm3(Predicted)
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- Acetic Acid (Very Slightly, Heated), Acetonitrile (Slightly), DMSO (Slightly)
- form
- Solid
- pka
- 6.11±0.40(Predicted)
- color
- White to Pale Beige
- Stability:
- Hygroscopic
- InChIKey
- YFVGIJBUXMQFOF-BWLJPJRBNA-N
- SMILES
- C12C(O)=CC(O[C@H]3[C@H](O)[C@H]([C@H](O)[C@@H](CO[C@@H]4O[C@H]([C@H](O)[C@@H](O)[C@H]4O)C)O3)O)=CC=1OC(C1C=CC(OC)=CC=1)=CC2=O |&1:6,7,9,10,12,15,17,18,20,22,r|
- CAS DataBase Reference
- 480-36-4(CAS DataBase Reference)
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Safety Information
- Safety Statements
- 22-24/25
- HS Code
- 29389090
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Linarin Usage And Synthesis
Chemical Properties
White crystalline powder, easily soluble in methanol, almost insoluble in ether, derived from wild chrysanthemum, great thistle, and small thistle.
Uses
Linarine (Diosmin EP Impurity E) is a naturally occurring flavone glycoside that was identified to possess potential sedative and anticonvulsant properties.
in vivo
Linarin (oral administration; 50-150 mg/kg; 8 weeks) can improve bone loss in ovariectomized mice[2].
| Animal Model: | Ovariectomy treated female C57/BL6 mice[2] |
| Dosage: | 50 and 150 mg/kg |
| Administration: | Oral administration (p.o.); 8 weeks |
| Result: | Dose?dependently preserved the trabecular bone microarchitecture of ovariectomized mice. Slightly increased BMD compared to the control OVX group. Significantly decreased OVX-induced serum ALP and OCN levels. |
IC 50
AChE
LinarinSupplier
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