1,4,7,10,13-PENTAOXA-16-AZACYCLOOCTADECANE Chemical Properties

Melting point:

46-49 °C (lit.)

Boiling point:

406.57°C (rough estimate)

Density 

1.1122 (rough estimate)

refractive index 

1.4287 (estimate)

Flash point:

>230 °F

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

8.69±0.20(Predicted)

form 

powder to crystaline

color 

White to Light yellow to Light orange

Water Solubility 

Insoluble in water.

Sensitive 

Air Sensitive

BRN 

1074079

CAS DataBase Reference

33941-15-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

F 

3-10

HS Code 

29349990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

1,4,7,10,13-PENTAOXA-16-AZACYCLOOCTADECANE Usage And Synthesis

Chemical Properties

white to light yellow crystals or crystalline mass

Uses

1-Aza-18-crown-6 is used as building block for the synthesis of bis-crown ethers, lariat ethers and other monofunctionalized macrocycles. It is also used as pharmaceutical intermediate.

Synthesis

To a 3L three-necked round-bottomed flask was sequentially added a magnetic stirrer, 1.50 L of tert-butanol (tBuOH) and potassium tert-butanol (KOtBu, 30.7 g, 274 mmol). The mixture was heated to 40 °C with continuous stirring for 30 min to ensure complete dissolution of KOtBu. Subsequently, tetraethylene glycol di-p-toluenesulfonate (46 g, 91.5 mmol, dissolved in 100 mL of dioxane) and diethanolamine (9.6 g, 91.3 mmol, dissolved in 100 mL of tBuOH), respectively, were slowly added dropwise to the reaction system over a period of 2 hours through two different dropping funnels. Note: The rate of titration has a significant effect on the reaction yield, and slow titration helps to increase the yield. After dropwise addition, the reaction mixture was continued to be stirred for 1 hour and subsequently cooled to room temperature. The reaction mixture was filtered through a Brinell funnel and the solvent was removed by rotary evaporator. To the residual brown viscous mass was added 100 mL of deionized water and extracted first with hexane (1 x 60 mL, discarding the hexane phase) and then with dichloromethane (CH2Cl2, 5 x 60 mL). The dichloromethane phases were combined, dried with anhydrous magnesium sulfate (MgSO4) and the solvent was again removed by rotary evaporator. The resulting dark brown residue was distilled under high vacuum through a ball-bulb distillation apparatus using a hot air gun for assisted heating, resulting in the colorless liquid-like product az-18-crown ether-6 (8.4 g, 35% yield). The nuclear magnetic resonance (NMR) spectrum of the product was consistent with the data reported in the literature. It was found that the tBuOH used in the reaction could be recovered by distillation and used in the subsequent synthesis of aza-crown ether even though it contained a small amount of dioxane (<5%).

References

[1] Bulletin of the Chemical Society of Japan, 1983, vol. 56, # 1, p. 212 - 218
[2] Polyhedron, 2018, vol. 141, p. 385 - 392
[3] Phosphorus, Sulfur and Silicon and the Related Elements, 2006, vol. 181, # 1, p. 219 - 225
[4] Journal of the Chemical Society, Chemical Communications, 1981, # 10, p. 471 - 472

1,4,7,10,13-PENTAOXA-16-AZACYCLOOCTADECANE(33941-15-0)Related Product Information

• Aza-15-crown-5
• 18-Crown-6
• Isobutyl iodide
• 4,13-Diaza-18-crown 6-ether
• 1,4,7,10,13-PENTAOXA-16-AZACYCLOOCTADECANE
• 2-[2-(2-AMINOETHOXY)ETHOXY]ETHANOL
• 1-AMINO-3,6,9-TRIOXAUNDECANYL-11-OL
• N-METHOXYMETHYLAZA-18-CROWN-6, 96
• (14R*,18R*)-14,18-dimethyl-1,4,7,10,13-pentaoxa-16-azacyclooctadecane
• 16-[2-(2-Methoxyethoxy)ethyl]-1,4,7,10,13-pentaoxa-16-azacyclooctadecane
• 16-(2-Methoxyethyl)-1,4,7,10,13-pentaoxa-16-azacyclooctadecane
• 16,16'-Pentamethylenebis(1,4,7,10,13-pentaoxa-16-azacyclooctadecane)
• 16-[(4-methylphenyl)sulfonyl]-1,4,7,10,13-pentaoxa-16-azacyclooctadecane
• 16,16'-[Oxybis(ethylene)]bis[1,4,7,10,13-pentaoxa-16-azacyclooctadecane]
• 16-Heptyl-1,4,7,10,13-pentaoxa-16-azacyclooctadecane
• (14S,18S)-14,18-Dimethyl-1,4,7,10,13-pentaoxa-16-azacyclooctadecane
• 1,4,7,10,13-pentaoxa-16-azacyclooctadecane-16-carbonitrile
• 6-AMINO-1-(1,4,7,10,13-PENTAOXA-16-AZA-CYCLOOCTADEC-16-YL)-HEXAN-1-ONE