Picroside II
Picroside II Basic information
- Product Name:
- Picroside II
- Synonyms:
-
- 6'-VANILLOYL CATALPOL
- AMPHICOSIDE
- PICROSIDE II
- PICROSID II
- beta-d-Glucopyranoside, 1a,1b,2,5a,6,6a-hexahydro-6-[(4-hydroxy-3-methoxybenzoyl)oxy]-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl, [1aS-(1aalpha,1bbeta,2beta,5abeta,6beta,6aalpha)]-
- AMPHICOSIDE II
- PICROSIDE ò
- (1aS-(1aalpha,1bbeta,2beta,5abeta,6beta,6aalpha))-1a,1b,2,5a,6,6a-Hexahydro-6-((4-hydroxy-3-methoxybenzoyl)oxy)-1a-(hydroxymethyl)oxireno(4,5)cyclopenta(1,2-c)pyran-2-yl-beta-D-glucopyranoside
- CAS:
- 39012-20-9
- MF:
- C23H28O13
- MW:
- 512.46
- EINECS:
- 254-247-6
- Product Categories:
-
- Inhibitors
- Miscellaneous Natural Products
- Iridoids
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Mol File:
- 39012-20-9.mol
Picroside II Chemical Properties
- Melting point:
- 145 - 155oC
- Boiling point:
- 780.8±60.0 °C(Predicted)
- Density
- 1.66±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- ethanol: soluble1mg/mL, clear, colorless
- pka
- 8.07±0.20(Predicted)
- form
- Solid
- color
- Pale Yellow
- InChIKey
- AKNILCMFRRDTEY-MRFBWRKESA-N
Safety Information
- Safety Statements
- 24/25
- WGK Germany
- 3
- HS Code
- 29389090
Picroside II Usage And Synthesis
Uses
Picroside II similar to Picroside I (P437635), acts as an oxygen free radical scavenger and thus promotes anti-inflammatory activity and may be used in the treatment of arthritis or ischemic injury.
Uses
Picroside II similar to Picroside I (P437635), acts as an oxygen free radical scavenger and thus promotes anti-inflammatory activity and may be used in the treatment of arthritis or ischemic injury.
Definition
ChEBI: Picroside ii is a tannin.
Biological Activity
Picroside II displaysmany anti-cancer properties such as anti-metastatic, anti-angiogenic, and anti-apoptotic activities in both in vitro and in vivo studies.It also exerts antioxidant, anti-inflammatory, and antidiarrheal effectsagainst acute oxidative injuries such as severe acute pancreatitis-inducedintestinal barrier injury. PII has protective effects onischemia/reperfusion (I/R)-induced injury by interacting with differentmechanisms in various in vitro and in vivo models.', 'Phytochemical found in Traditional Chinese Medicine herbal preparations. Picroside II, a glucoside, is reported to have hepatoprotective, cardioprotective, and neuroprotective properties.
in vivo
Picroside II (0-20 mg/kg, i.g., given in two doses) protects liver cells from damage and prevents apoptosis[1].
Picroside II (20 mg/kg, intravenous injection, given in four doses) inhibits the activation of NLRP3 inflammasome and NF-κB pathway in mice, reducing the inflammatory response in sepsis and enhancing immune function[3].
Picroside II (20 mg/kg, intraperitoneal injection, a single dose) protects the blood-brain barrier by inhibiting oxidative signaling pathways in a rat model of ischemia-reperfusion injury[4].
Picroside II (5-20 mg/kg, i.g., once a day for seven days) has anti-lipid peroxidation effects and protects against mitochondrial damage in mice with liver injury[5].
| Animal Model: | DGalN and LPS(HY-D1056)-induced acute liver injury in mice[1] |
| Dosage: | 0, 5, 10, 20 mg/kg; administered 10 min before and 4 h after D-GalN and LPS administration |
| Administration: | i.g. |
| Result: | Reduced the levels of alanine aminotransferase and aspartate aminotransferase in the serum, decreased MDA content, had a dose-dependent effect on hepatocyte apoptosis, and upregulated the expression of the bcl-2 gene. |
| Animal Model: | Sepsis mouse model[3] |
| Dosage: | 20 mg/kg; four times injected (2 h, 14 h, 26 h and 38 h after CLP) |
| Administration: | Intravenous injection (i.v.) |
| Result: | Improved survival, reduced sepsis-related infiltration and attenuated lung injury, enhanced bacterial clearance, reduced IL-6, IL-1β, and TNF-α levels, inhibited splenic lymphocyte apoptosis, reduced p-NF-κB (p65) expression, and reduced IL-1β and caspase-1 levels. |
| Animal Model: | Rats with cerebral ischemia-reperfusion injury[4] |
| Dosage: | 20 mg/kg; single dose |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Reduced the nervous system score, neuronal injury, BBB damage, ROS content and NADPH oxidase activity, down-regulated the protein levels of Rac-1, Nox2, ROCK, MLCK and MMP-2, and up-regulated the expression of claudin-5. |
| Animal Model: | Mouse model of liver injury induced by CCl4, D-GalN and AP[5] |
| Dosage: | 5, 10, 20mg/kg; daily; 7 days |
| Administration: | i.g. |
| Result: | Reduced the high levels of ALT and AST in serum caused by CCl4, D-GalN and AP, significantly alleviated liver cell damage, reduced MDA, and increased SOD and GSH-Px content in a dose-dependent manner, inhibited AP-induced liver toxicity in mice, enhanced ATPase activity, and improved mitochondrial swelling. |
Picroside IISupplier
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Picroside II(39012-20-9)Related Product Information
- Catalpol
- PICROSIDE I
- Vanillic acid
- Propylparaben
- Ethyl 3,4-dihydroxybenzoate
- 2-Methyl-2,3-epoxy-1-propanol
- 4-HYDROXYBENZOIC ACID ISOAMYL ESTER
- HEPTYL-BETA-D-GLUCOPYRANOSIDE
- Cyclopentene oxide
- 1,2-EPOXY-3-METHYLBUTANE
- Butylparaben
- 2-Benzyloxyethanol
- (2-ISOPROPOXYETHYL) ACETATE
- 1-Methylcyclopentanol
- 1,3-CYCLOPENTANEDIOL
- ISOBUTYL BENZOATE
- 1,1,3-TRIMETHOXYBUTANE
- Aucubin