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5-Iodouracil

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5-Iodouracil Basic information

Product Name:
5-Iodouracil
Synonyms:
  • 2,4-DIHYDROXY-5-IODOPYRIMIDINE
  • 5IU
  • 5-IODOURACIL
  • 5-IODO-1H-PYRIMIDINE-2,4-DIONE
  • 5-IODO-2,4-(1H,3H)-PYRIMIDINEDIONE
  • TIMTEC-BB SBB009920
  • 5-Iodouracil,97%
  • 2,4(1H,3H)-Pyrimidinedione, 5-iodo-
CAS:
696-07-1
MF:
C4H3IN2O2
MW:
237.98
EINECS:
211-788-2
Product Categories:
  • Biochemistry
  • Nucleobases and their analogs
  • Nucleosides, Nucleotides & Related Reagents
  • Nucleic acids
Mol File:
696-07-1.mol
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5-Iodouracil Chemical Properties

Melting point:
274-276 °C (dec.) (lit.)
Density 
2.2076 (estimate)
storage temp. 
2-8°C
solubility 
Very faint turbidity in NH3aq. Soluble in 1M NaOH.
pka
7.02±0.10(Predicted)
form 
Fluffy Powder
color 
White to light yellow
Water Solubility 
SOLUBLE IN COLD WATER
Sensitive 
Light Sensitive
BRN 
4891
CAS DataBase Reference
696-07-1(CAS DataBase Reference)
NIST Chemistry Reference
5-Iodouracil(696-07-1)
EPA Substance Registry System
2,4(1H,3H)-Pyrimidinedione, 5-iodo- (696-07-1)
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Safety Information

Hazard Codes 
T,Xi
Risk Statements 
46-20/21/22-36/37/38
Safety Statements 
53-22-26-36/37/39-45
RIDADR 
2811
WGK Germany 
3
RTECS 
YR0525000
Hazard Note 
Irritant/Carcinogenic/Light Sensitive
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29335990

MSDS

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5-Iodouracil Usage And Synthesis

Chemical Properties

white to light yellow fluffy powder

Uses

5-Iodouracil is a halogenated pyrimidine that can be used in nucleoprotein photo-crosslinking via RNA substitution. 5-Iodouracil is used in thymidine phosphorylase targeted imaging and therapy. Studies show that DNA N-glycosylase MED1 exhibited higher preference for 5-Iodouracil and halogenated bases over non-halogenated ones.

Definition

ChEBI: An organoiodine compound consisting of uracil having an iodo substituent at the 5-position.

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