Bezlotoxumab Chemical Properties

form 

Liquid

color 

Colorless to light yellow

Bezlotoxumab Usage And Synthesis

Uses

Bezlotoxumab is a human monoclonal antibody directed against C. difficile toxin B. Bezlotoxumab binds to C. difficile toxin B preventing intestinal epithelial damage and colitis[1].

Clinical Use

Human monoclonal antitoxin antibody:

Prevention of recurrence of Clostridium difficile infection

Metabolism

Bezlotoxumab is catabolized through protein degradation processes; metabolism does not contribute to its clearance. It is eliminated from the body primarily by protein degradation.

References

[1] Navalkele BD, et, al. Bezlotoxumab: an emerging monoclonal antibody therapy for prevention of recurrent Clostridium difficile infection. Biologics. 2018 Jan 18;12:11-21. DOI:10.2147/BTT.S127099

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