2-Amino-5,7-dimethoxy-1,2,4-triazolo[1,5-a]pyrimidine Chemical Properties

Density 

1.61±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

3.85±0.30(Predicted)

CAS DataBase Reference

13223-43-3(CAS DataBase Reference)

EPA Substance Registry System

[1,2,4]Triazolo[1,5-a]pyrimidin-2-amine, 5,7-dimethoxy- (13223-43-3)

2-Amino-5,7-dimethoxy-1,2,4-triazolo[1,5-a]pyrimidine Usage And Synthesis

Chemical Properties

White solid

Uses

5,7-Dimethoxy-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine is a useful research chemical compound used in the preparation of N-(5,7-dimethoxy[1,2,4]triazolo[1,5-a]pyrimidin-2-yl) arylsulfonamides as herbicides.

Synthesis

The general procedure for the synthesis of 2-amino-5,7-dimethoxy-1,2,4-triazino[1,5-a]pyrimidine from the compound (CAS:102739-44-6) was as follows: 3a (114.5 g, 0.4 mol) and hydroxylamine hydrochloride (40.3 g, 0.58 mol) were dissolved in ethanol (600 mL) and stirred vigorously at 60 °C for 0.5 hours. Subsequently, triethylamine (58.7 g, 0.58 mol) was slowly added dropwise to the reaction mixture. The resulting mixture was refluxed for 5 h. After completion of the reaction, it was cooled to room temperature. The white solid of product 4a was collected by filtration and washed with 200 mL of water to give 71.4 g of product in 91.5% yield.

References

[1] Heterocycles, 2016, vol. 92, # 5, p. 829 - 843
[2] Patent: CN105399746, 2016, A. Location in patent: Paragraph 0077-0078
[3] Patent: US2002/111361, 2002, A1

2-Amino-5,7-dimethoxy-1,2,4-triazolo[1,5-a]pyrimidine(13223-43-3)Related Product Information

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• CHEMBRDG-BB 4006205