N-Methyl-4-piperidinol Chemical Properties

Melting point:

29-31 °C(lit.)

Boiling point:

200 °C(lit.)

Density 

0.98 g/mL at 20 °C(lit.)

vapor pressure 

8.13-11Pa at 25℃

refractive index 

n20/D 1.479

Flash point:

190 °F

storage temp. 

2-8°C

form 

Liquid After Melting

pka

14.87±0.20(Predicted)

color 

Clear colorless to brown

Water Solubility 

MISCIBLE

Sensitive 

Hygroscopic

BRN 

103024

LogP

-0.14-0.756 at 25℃

CAS DataBase Reference

106-52-5(CAS DataBase Reference)

NIST Chemistry Reference

4-Hydroxy-N-methylpiperidine(106-52-5)

EPA Substance Registry System

4-Piperidinol, 1-methyl- (106-52-5)

Safety Information

Hazard Codes 

Xi,C

Risk Statements 

37/38-41-36/37/38-34

Safety Statements 

26-37/39-45-36/37/39-27

WGK Germany 

3

Hazard Note 

Irritant

TSCA 

Yes

HS Code 

29333999

MSDS

• Language:English Provider:1-Methyl-4-piperidinol
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

N-Methyl-4-piperidinol Usage And Synthesis

Chemical Properties

clear colorless to yellowish liquid after melting

Uses

Reactant for:• ;Optimization of Novobiocin scaffold to product antitumor agents1• ;Substitution about the rigidifying ring for histamine H4 receptor antagonist synthesis2Reactant for synthesis of:• ;CaMKII inhibitors3• ;VEGFR and FGFR kinase inhibitors4• ;Phosphoinositide-3-kinase inhibitors5• ;Protein lysine methyltransferase G9a inhibitors6

Uses

4-Hydroxy-1-methylpiperidine is used as reactant for optimization of Novobiocin scaffold to product antitumor agents, substitution about the rigidifying ring for histamine H4 receptor antagonist synthesis. It is also used as a reactant in the synthesis of CaMKII, VEGFR and FGFR kinase inhibitors and Phosphoinositide-3-kinase, Protein lysine methyltransferase G9a inhibitors.

Flammability and Explosibility

Not classified

N-Methyl-4-piperidinol (106-52-5)Related Product Information

• 1-Methyl-4-piperidone
• Tribenuron methyl
• Thiophanate-methyl
• Pirimiphos-methyl
• Triacetonediamine
• Kresoxim-methyl
• Haloperidol
• Methyl salicylate
• METSULFURON METHYL
• 2,2,6,6-Tetramethyl-4-piperidinol
• Methyl acetate
• CHLOROPHOSPHONAZO III
• Methyl
• STRYCHNINE
• 1-BENZYL-4-CYANO-4-HYDROXYPIPERIDINE
• Tropine
• Parathion-methyl
• 10,11-Dimethoxystrychnine