(R)-(-)-2-Aminobutane Chemical Properties

Melting point:

-105°C

alpha 

-7.5 º (c=neat 19 ºC)

Boiling point:

63 °C(lit.)

Density 

0.72 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.393(lit.)

Flash point:

-19°C

storage temp. 

Flammables area

pka

10.74±0.10(Predicted)

form 

clear liquid

color 

Colorless to Almost colorless

optical activity

[α]19/D 7.5°, neat

Water Solubility 

> 10 mg/L

Sensitive 

Air Sensitive

Merck 

14,1544

BRN 

1718760

CAS DataBase Reference

13250-12-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

F,C,N,F+

Risk Statements 

11-34-50-35-20/22

Safety Statements 

16-26-36/37/39-45-9-61-28A-28

RIDADR 

UN 2733 3/PG 2

WGK Germany 

3

F 

10-23

HazardClass 

3

PackingGroup 

II

HS Code 

29211999

MSDS

• Language:English Provider:(R)-(-)-2-Aminobutane

(R)-(-)-2-Aminobutane Usage And Synthesis

Chemical Properties

Colorless to light yellow liqui

Uses

(R)-(-)-2-Aminobutane is a chiral amine plays an important role in pharmaceutical chemistry and in organic synthesis as chiral auxiliary, which is used to determine the enantiomeric excess (ee).

Uses

(R)-(?)-sec-Butylamine can be used:

• To prepare (R)-(?)-sec-butylbis(2-hydroxyethyl)amine, an intermediate for the synthesis of aminodiphosphine ligands.
• As a substrate to demonstrate the stereochemistry of Mitsunobu reaction in the synthesis of secondary amines.
• As a model compound in the study of singlet-triplet transitions in circular dichroism.

Purification Methods

Dry it over solid NaOH overnight and fractionate it through a short helices packed column. The L-hydrogen tartrate salt has m 139-140o (from H2O), the 1H2O has m 96o []D +18.1o (c 11, H2O), the hydrochloride has m 152o [ ] 21 -1.1o (c 13, H2O) and the benzoyl derivative crystallises from EtOH as needles with m 97o, [] 21 -34.9o (c 11, H2O). [Bruck et al. J Chem Soc 921 1956,Kjaer & Hansen Acta Chem Scand 11 898 1957.] [Beilstein 4 H 161, 4 I 372, 4 III 308, 4 IV 617.] The S -(+)-enantiomer has has same properties except for the optical rotation which has the opposite sign.

(R)-(-)-2-Aminobutane(13250-12-9)Related Product Information

• 1,2,3,4-Butanetetracarboxylic acid
• ISOBUTANE
• 1-Chlorobutane
• n-Butane
• 1-Chloro-2-methylpropane
• 1-Bromo-2-methylpropane
• 1-Bromobutane
• 2,2-DICHLOROBUTANE
• NITROCYCLOPENTANE
• TPCK
• 1,8-DIAMINO-P-MENTHANE
• Cyclobutylamine
• N-ALPHA-BENZOYL-L-ARGININE
• 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE
• 1-ETHYNYLCYCLOHEXYLAMINE
• sec-Butylamine
• Aminobutane,1-Aminobutane, n-Butylamine,1-AMINOBUTANE
• Nalpha-Cbz-L-Arginine