Uridine-5'-triphosphoric acid trisodium salt Chemical Properties

Melting point:

140 °C

Flash point:

113 °C

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

solubility 

H2O: soluble25 mg of UTP in 0.5 ml of solvent, clear, colorless

form 

Powder

color 

White

Water Solubility 

75 g/100 mL (20 ºC)

BRN 

3585234

InChI

InChI=1/C9H15N2O15P3.Na.H/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18);;/t4-,6-,7-,8-;;/s3

InChIKey

IKVGSWYKOMJBSB-RFFBCSJBNA-N

SMILES

O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1N1C=CC(=O)NC1=O)O.[NaH] |&1:1,2,3,19,r|

CAS DataBase Reference

19817-92-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

20/21/22-68/20/21/22-68-36/37/38

Safety Statements 

22-26-36-36/37-24/25

WGK Germany 

1

RTECS 

YU8083000

HS Code 

29349990

Uridine-5'-triphosphoric acid trisodium salt Usage And Synthesis

Description

Uridine-5'-triphosphoric acid trisodium salt, also known as UTP, is a polyphosphate analogue of uridine that is used in the synthesis of agonists at the G-protein-coupled P2Y receptors.

Chemical Properties

White crystalline powder

Uses

psychostimulant

Uses

P2Y receptor agonist.

Uses

Uridine-5'-triphosphoric acid trisodium salt is a polyphosphate analogue of the nucleoside uridine used in the preparation of potent and selective agonists at the G-protein-coupled P2Y receptors.

Application

Uridine-5'-triphosphoric acid trisodium salt solution can be used to increase intracellular Ca2+ levels in rat primary tracheal epithelial cells. It is also used as a nucleotide substrate to analyze the activity of MutT homolog 1 (MTH1).

Biochem/physiol Actions

Uridine-5′-Triphosphate?(UTP) is a cytosolic nucleotide component of nucleic acids. It serves as a signaling molecule in the extracellular space. Uridine-5′-Triphosphate?(UTP) is involved in various pathophysiological responses in the nervous system.?UTP also plays a major role in the regeneration process.

in vitro

Uridine triphosphate (UTP) (0, 10, 100, 250, 500, and 1000 μM; 2, 4, 6, 8, 10, and 12 h) trisodium salt enhances RT4-D6P2T cells migration and wound repair. Uridine triphosphate trisodium salt induces Schwannoma cell migration through the activation of P2Y2 receptors and the increase of extracellular MMP-2 activation and expression. Uridine triphosphate (UTP) trisodium salt (Uridine-5'-triphosphoric acid trisodium salt) evokes MAPK phosphorylation in a biphasic pattern MAPK phosphorylation, with an early transient phosphorylation 5 min after treatment and a late and sustained phosphorylation that appeared at 6 h and lasted up to 24 h.

Uridine-5'-triphosphoric acid trisodium salt(19817-92-6)Related Product Information

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