Guanosine-5'-triphosphate disodium salt Chemical Properties

Melting point:

180°C

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

solubility 

PBS (pH 7.2): 10 mg/ml

form 

Powder

color 

White

Water Solubility 

Soluble in water.

InChIKey

XIZYETZGWBYYEH-NGPBCCOENA-N

SMILES

O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1N1C=NC2C(NC(N)=NC1=2)=O)O.[NaH] |&1:1,2,3,19,r|

CAS DataBase Reference

56001-37-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-27-36/37/39-36

WGK Germany 

3

F 

10-21

HS Code 

29349990

MSDS

• Language:English Provider:Guanosine-5'-triphosphoric aicd disodium salt

Guanosine-5'-triphosphate disodium salt Usage And Synthesis

Description

Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein (G proteins) signalling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate disodium salt holds promise for research in biosynthesis and skeletal muscle regeneration.

Chemical Properties

White crystalline powder

Uses

A phosphoryl donor in protein synthesis and signal transduction

Uses

Guanosine 5?-triphosphate (GTP), a purine trinucleotide, is a substrate for RNA polymerases and a wide range of GTPase including G-protein coupled receptor (GPCR) GTPases and cell signaling and cycling associated guanine nucleotide exhange factors (GEF). Guanosine 5?-Triphosphate, Disodium Salt is a phosphoryl donor in protein synthesis and in signal transduction.

in vitro

Guanosine-5'-triphosphate disodium salt (500 μM, 24 hours) significantly promoted the upregulation of miR133a, miR133b, and myogenic regulatory factors Pax7, MyoD, and Myogenin in differentiated human myogenic precursor cells (MPCs).
Guanosine-5'-triphosphate disodium salt (5'-GTP trisodium salt) (500 μM, 24 h) can induce the release of exosomes from human myogenic progenitor cells.

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