Dopexamine hydrochloride Chemical Properties

Melting point:

213-215°C

storage temp. 

2-8°C

solubility 

Soluble in water, sparingly soluble in ethanol (96 per cent) and in methanol, practically insoluble in acetone.

form 

Solid

color 

White to Light Grey

Stability:

Hygroscopic

Dopexamine hydrochloride Usage And Synthesis

Chemical Properties

White or almost white, crystalline powder.

Uses

Dopexamine is a synthetic dopamine analog and acts as a a β2-adrenergic receptor agonistt as well as an agonist at peripheral dopamine receptors. Dopexamine has been used to improve myocardial and renal performance in patients suffering from low cardiac output states.

Uses

Dopexamine is a synthetic dopamine analog and acts as a a β2-adrenergic receptor agonistt as well as an agonist at peripheral dopamine receptors. Dopexamine hydrochloride has been used to improve myocardial and renal performance in patients suffering from low cardiac output states.

brand name

Dopacard (Fisons).

Clinical Use

Inotropic support in exacerbations of heart failure and heart failure associated with cardiac surgery

Drug interactions

Potentially hazardous interactions with other drugs
Anaesthetics: risk of ventricular arrhythmias with isoflurane - avoid.
Antidepressants: risk of hypertensive crisis with MAOIs and moclobemide.
Beta-blockers: risk of severe hypertension
Dopaminergics: avoid with rasagiline.
Sympathomimetics: effects of adrennoradrenaline possibly enhanced.

Metabolism

Dopexamine is rapidly eliminated from blood with a halflife of approximately 6-7 minutes in healthy volunteers and around 11 minutes in patients with cardiac failure. Subsequent elimination of the metabolites is by urinary and biliary excretion.

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