Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  API >  Antibiotics >  Penicillins drugs >  pheneticillin

pheneticillin

Basic information Safety Supplier Related

pheneticillin Basic information

Product Name:
pheneticillin
Synonyms:
  • pheneticillin
  • (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(2-phenoxypropionyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
  • 6α-[(1-Oxo-2-phenoxypropyl)amino]penicillanic acid
  • 1-Phenoxyethylpenicillin
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-(2-phenoxypropionamido)- (7CI, 8CI)
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(1-oxo-2-phenoxypropyl)amino]-, (2S,5R,6R)- (9CI)
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(1-oxo-2-phenoxypropyl)amino]-, [2S-(2a,5a,6b)]-
  • Alfacilin
CAS:
147-55-7
MF:
C17H20N2O5S
MW:
364.42
EINECS:
2056914
Mol File:
147-55-7.mol
More
Less

pheneticillin Chemical Properties

Boiling point:
673.9±55.0 °C(Predicted)
Density 
1.41±0.1 g/cm3(Predicted)
pka
2.44±0.50(Predicted)
More
Less

pheneticillin Usage And Synthesis

Originator

Syncillin, Bristol, US ,1959

Uses

Phenethicillin is a penicillin antibiotic medication.

Definition

ChEBI: A penicillin in which the substituent at position 6 of the penam ring is a 2-phenoxypropanamido group.

Manufacturing Process

Triethylamine (1.5 ml) was added to a cold solution (10°C) of αphenoxypropionic acid (1.66 g, 0.01 mol) in 15 ml of pure dioxane, with stirring and cooling to 5°C to 10°C while isobutyl chloroformate (1.36 g, 0.01 mol) in 5 ml of dioxane was added dropwise. Then the mixture was stirred for ten minutes at 5°C to 8°C. A solution of 6-amino-penicillanic acid (2.16 g, 0.01 mol) in 15 ml of water and 2 ml of triethylamine was then added dropwise while the temperature was maintained below 10°C. The resulting mixture was stirred in the cold for 15 minutes then at room temperature for 30 minutes, diluted with 30 ml of cold water and extracted with ether which was discarded. The cold aqueous solution was then covered with 75 ml of ether and acidified to pH 2 with 5 N H2SO4. After shaking, the ether layer containing the product 6-(α-phenoxypropionamido)penicillanic acid, was dried for ten minutes over anhydrous sodium sulfate and filtered. Addition of 6 ml of dry n-butanol containing 0.373 g/ml of potassium 2-ethylhexanoate precipitated the potassium salt of the product as a colorless oil which crystallized on stirring and scratching and was collected, dried in vacuo and found to weigh 2.75 g, to melt at 217°C to 219°C.

brand name

Chemipen (Bristol-Myers Squibb); Syncillin (Bristol-Myers Squibb) [Name previously used: Phenethicillin.].

Therapeutic Function

Antibacterial

pheneticillin Supplier

Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Email
waley188@sohu.com
Alta Scientific Co., Ltd.
Tel
022-6537-8550 15522853686
Email
sales@altasci.com.cn
Shanghai Han-Xiang Chemical Co., Ltd.
Tel
15971444841
Email
amber@biochempartner.com
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-029-89586680 +86-18192503167
Email
1026@dideu.com