Penicillins drugs
Mechanism
penicillin can inhibit the synthesis of bacterial cell wall, leading to the production and activation of autolysis enzymes, resulting in bacterial death. For this group of drugs, different varieties target on different penicillin-binding proteins and enzymes with these proteins and enzymes being involved in bacterial cell wall metabolism.
Indications
they have bactericidal effect during the reproduction period of bacteria. Gram-positive cocci: Streptococcus, pneumococcus, sensitive staphylococcus; and some kinds of gram-negative cocci: to Neisseria meningitidis, Neisseria gonorrhoeae, they have strong antibacterial effects. Clostridium bacilli: Corynebacterium diphtheriae; spirochete, Treponema pallidum, borrelia recurrentis, and Leptospira; they are also applicable to various kinds of inflection diseases caused by Clostridium bacillus, Tetanus bacilli, Clostridium welchii and actinomycetes; for example, various kinds of suppurative skin disease, skin bacterial infections, gonorrhea, syphilis and so on.
Contraindications
patients who are allergic to penicillin and have a history of allergy should be disabled.
Adverse reactions
1. Allergic reaction
2. Gastrointestinal discomfort.
Precautions
1. Probenecid can block the excretion of penicillin drugs with combination usage can cause the increase of its plasma concentration.
2. Before drug administration, people must be subject to skin test according to the provisions. Patients who are allergic to the procaine should be disabled from using the procaine penicillin.
3. Procaine penicillin can occasionally cause a specific reaction. Upon injection of drugs or after 1 ~2min, patients may get a series of symptoms such as feeling uncomfortable in the heart, getting endangered fear, dizziness, palpitations and auditory hallucinations. Generally there are no breathing disorders and circulatory disorders occurring. For the majority of cases can be elevated blood pressure. Generally this doesn’t require special treatment. The symptoms will be automatically relived after 1 ~ 2h. Application of sedatives and antihistamines can help to restore.
4. Low-dose of penicillin does not cause toxicity. Large doses of application may cause neuropsychiatric symptoms. For patients with hemagglutination defects, high-dose of penicillin can disrupt the blood clotting mechanism, thereby leading to bleeding tendency.
5. The aqueous solution of penicillin sodium and potassium salt are unstable, thus should be used now with.
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- Structure:
- Chemical Name:
- Ampicillin
- CAS:
- 7177-48-2
- MF:
- C16H25N3O7S
- Structure:
- Chemical Name:
- WORTMANNIN
- CAS:
- 19545-26-7
- MF:
- C23H24O8
- Structure:
- Chemical Name:
- Oxacillin sodium monohydrate
- CAS:
- 7240-38-2
- MF:
- C19H20N3NaO6S
- Structure:
- Chemical Name:
- Ampicillin sodium
- CAS:
- 69-52-3
- MF:
- C16H20N3NaO4S
- Structure:
- Chemical Name:
- Procaine penicilline G hydrate
- CAS:
- 6130-64-9
- MF:
- C29H38N4O6S
- Structure:
- Chemical Name:
- Penicillin V-D5
- MF:
- C16H18N2O5S
- Structure:
- Chemical Name:
- Meropenem Trihydrate
- CAS:
- 119478-56-7
- MF:
- C17H27N3O6S
- Chemical Name:
- AMOXICILLIN AND CLAVULANATE POTASSIUM
- Structure:
- Chemical Name:
- Penicillin G sodium salt
- CAS:
- 69-57-8
- MF:
- C16H17N2NaO4S
- Structure:
- Chemical Name:
- Sodium cloxacillin monohydrate
- CAS:
- 7081-44-9
- MF:
- C19H19ClN3NaO6S
- Structure:
- Chemical Name:
- Carbenicillin disodium
- CAS:
- 4800-94-6
- MF:
- C17H19N2NaO6S
- Structure:
- Chemical Name:
- Piperacillin sodium salt
- CAS:
- 59703-84-3
- MF:
- C23H26N5NaO7S
- Structure:
- Chemical Name:
- Cloxacillin benzathine
- CAS:
- 23736-58-5
- MF:
- C35H38ClN5O5S
- Structure:
- Chemical Name:
- Ampicillin
- CAS:
- 69-53-4
- MF:
- C16H19N3O4S
- Structure:
- Chemical Name:
- Penicillin G potassium salt
- CAS:
- 113-98-4
- MF:
- C16H17KN2O4S
- Chemical Name:
- PENICILLINASE
- CAS:
- 9001-74-5
- Structure:
- Chemical Name:
- Amoxicillin
- CAS:
- 26787-78-0
- MF:
- C16H19N3O5S
- Structure:
- Chemical Name:
- Penicillin V Benzathine
- CAS:
- 63690-57-3
- MF:
- C16H20N2.2C16H18N2O5S
- Structure:
- Chemical Name:
- Piperacillin
- CAS:
- 61477-96-1
- MF:
- C23H27N5O7S
- Structure:
- Chemical Name:
- OXACILLIN
- CAS:
- 66-79-5
- MF:
- C19H19N3O5S
- Structure:
- Chemical Name:
- CARBENICILLIN
- CAS:
- 4697-36-3
- MF:
- C17H18N2O6S
- Structure:
- Chemical Name:
- Benzathine benzylpenicillin
- CAS:
- 1538-09-6
- MF:
- C48H56N6O8S2
- Structure:
- Chemical Name:
- Flucloxacillin sodium
- CAS:
- 1847-24-1
- MF:
- C19H18ClFN3NaO5S
- Structure:
- Chemical Name:
- Procaine penicillin G
- CAS:
- 54-35-3
- MF:
- C29H38N4O6S
- Chemical Name:
- MAGNAMYCIN A PENICILLIN G
- Structure:
- Chemical Name:
- Penicillin G
- CAS:
- 61-33-6
- MF:
- C16H18N2O4S
- Structure:
- Chemical Name:
- CHLOMETHOCILLIN
- CAS:
- 1926-49-4
- MF:
- C17H18Cl2N2O5S
- Structure:
- Chemical Name:
- Penicillin V potassium salt
- CAS:
- 132-98-9
- MF:
- C16H17KN2O5S
- Structure:
- Chemical Name:
- Azlocillin sodium
- CAS:
- 37091-65-9
- MF:
- C20H22N5NaO6S
- Structure:
- Chemical Name:
- LENAMPICILLIN
- CAS:
- 86273-18-9
- MF:
- C21H23N3O7S
- Structure:
- Chemical Name:
- PENICILLIN-STREPTOMYCIN-NEOMYCIN
- MF:
- C61H105N15O30S
- Structure:
- Chemical Name:
- Amoxicillin sodium
- CAS:
- 34642-77-8
- MF:
- C16H20N3NaO5S
- Structure:
- Chemical Name:
- Mezlocillin sodium
- CAS:
- 59798-30-0
- MF:
- C22H27N6NaO9S2
- Structure:
- Chemical Name:
- Dicloxacillin sodium
- CAS:
- 13412-64-1
- MF:
- C19H20Cl2N3NaO6S
- Chemical Name:
- Penicillin&StreptoMycin&NeoMycin solution,γ-Irradiated
- Structure:
- Chemical Name:
- PENICILLIN V
- CAS:
- 87-08-1
- MF:
- C16H18N2O5S
- Structure:
- Chemical Name:
- METHICILLIN SODIUM (500 MG) (AS)
- CAS:
- 7246-14-2
- MF:
- C17H19N2O6S.Na.H2O
- Chemical Name:
- PENICILLIN G ALLERGY REAGENTS
- Chemical Name:
- AMOXYCILLIN Sodium sterile IP/Bp
- Chemical Name:
- PENICILLIN G PROCAINE USP(CRM STANDARD)
- Structure:
- Chemical Name:
- Sulbenicillin sodium
- CAS:
- 28002-18-8
- MF:
- C16H16N2Na2O7S2
- Structure:
- Chemical Name:
- OXACILLIN SODIUM
- CAS:
- 1173-88-2
- MF:
- C19H18N3NaO5S
- Structure:
- Chemical Name:
- Azlocillin
- CAS:
- 37091-66-0
- MF:
- C20H23N5O6S
- Structure:
- Chemical Name:
- Dicloxacillin
- CAS:
- 3116-76-5
- MF:
- C19H17Cl2N3O5S
- Chemical Name:
- EC 3.5.1.11
- CAS:
- 9014-06-6
- Structure:
- Chemical Name:
- APALCILLIN
- CAS:
- 63469-19-2
- MF:
- C25H23N5O6S
- Structure:
- Chemical Name:
- Mecillinam
- CAS:
- 32887-01-7
- MF:
- C15H23N3O3S
- Structure:
- Chemical Name:
- Ticarcillin
- CAS:
- 34787-01-4
- MF:
- C15H16N2O6S2
- Structure:
- Chemical Name:
- N-4-BENZYLOXYPHENYL ISOBUTYRYLACETAMIDE
- CAS:
- 265989-30-8
- MF:
- C19H21NO3
- Structure:
- Chemical Name:
- Flucloxacillin
- CAS:
- 5250-39-5
- MF:
- C19H17ClFN3O5S
- Structure:
- Chemical Name:
- Nafcillin sodium salt monohydrate
- CAS:
- 7177-50-6
- MF:
- C21H25N2NaO6S
- Structure:
- Chemical Name:
- Mezlocillin
- CAS:
- 51481-65-3
- MF:
- C21H25N5O8S2
- Structure:
- Chemical Name:
- LK-PENICILLIN IN PENICILLIN G THE DERIVATIVES
- CAS:
- 30034-13-0
- MF:
- C24H26N2O6S
- Chemical Name:
- D-PHENETHICILLIN POTASSIUM USP(CRM STANDARD)
- Structure:
- Chemical Name:
- TICARCILLIN DISODIUM SALT
- CAS:
- 29457-07-6
- MF:
- C15H17N2NaO6S2
- Structure:
- Chemical Name:
- 7-(2,2-DIMETHYL-5-OXO-4-PHENYL-IMIDAZOLIDIN-1-YL)-3,3-DIMETHYL-6-OXO-2-THIA-5-AZABICYCLO[3.2.0]HEPTANE-4-CARBOXYLIC ACID
- CAS:
- 3511-16-8
- MF:
- C19H23N3O4S
- Chemical Name:
- Procaine penicillin G(fortified)
- Chemical Name:
- TALAMPICILLIN HYDROCHLORIDE EPT(CRM STANDARD)
- Chemical Name:
- METICILLIN SODIUM WHO(CRM STANDARD)
- Structure:
- Chemical Name:
- BACAMPICILLIN
- CAS:
- 50972-17-3
- MF:
- C21H27N3O7S
- Structure:
- Chemical Name:
- Aspoxicillin
- CAS:
- 63358-49-6
- MF:
- C21H27N5O7S
- Structure:
- Chemical Name:
- CYCLACILLIN (200 MG)
- CAS:
- 3485-14-1
- MF:
- C15H23N3O4S
- Chemical Name:
- Penicillin G sodium buffered
- Chemical Name:
- PENICILLIN G BENZATHINE USP(CRM STANDARD)
- Chemical Name:
- AZLOCILLIN SODIUM USP(CRM STANDARD)
- Chemical Name:
- BENETHAMINE PENICILLIN BP(CRM STANDARD)
- Chemical Name:
- CLOXACILLIN BENZATHINE USP(CRM STANDARD)
- Structure:
- Chemical Name:
- PHENETHICILLIN POTASSIUM SALT
- CAS:
- 132-93-4
- MF:
- C17H19KN2O5S
- Structure:
- Chemical Name:
- TALAMPICILLIN
- CAS:
- 47747-56-8
- MF:
- C24H23N3O6S
- Chemical Name:
- FLUCLOXACILLIN SODIUM EPF(CRM STANDARD)
- Structure:
- Chemical Name:
- CARBENICILLIN PHENYL SODIUM
- CAS:
- 27025-49-6
- MF:
- C23H22N2O6S
- Structure:
- Chemical Name:
- BACAMPICILLIN HYDROCHLORIDE
- CAS:
- 37661-08-8
- MF:
- C21H28ClN3O7S
- Chemical Name:
- Penicillin G procaine/Potassium 3:1
- Chemical Name:
- Penicillin G potassium,non sterile
- Chemical Name:
- BENZATHINE BENZYLPENICILLIN EPB(CRM STANDARD)
- Chemical Name:
- 4-HYDROXY PHENOXYMETHYLPENICILLIN EPH(CRM STANDARD)
- Chemical Name:
- PIVMECILLINAM HYDROCHLORIDE EPP(CRM STANDARD)
- Chemical Name:
- BENETHAMINE PENICILLIN
- Structure:
- Chemical Name:
- Methicillin Sodium Salt
- CAS:
- 132-92-3
- MF:
- C17H19N2NaO6S
- Chemical Name:
- Penicillin G mixture
- Chemical Name:
- PENICILLIN V POTASSIUM USP(CRM STANDARD)
- Chemical Name:
- PENCILLIN G SODIUM USP(CRM STANDARD)
- Chemical Name:
- L-PHENETHICILLIN POTASSIUM USP(CRM STANDARD)
- Chemical Name:
- TICARCILLIN SODIUM EPT(CRM STANDARD)
- Structure:
- Chemical Name:
- SULBENICILLIN
- CAS:
- 41744-40-5
- MF:
- C16H18N2O7S2
- Structure:
- Chemical Name:
- almecillin
- CAS:
- 87-09-2
- MF:
- C13H18N2O4S2
- Chemical Name:
- Carbenicillin Disodium Salt
- Chemical Name:
- PENICILLIN V USP(CRM STANDARD)
- Chemical Name:
- PHENOXYMETHYLPENICILLIN POTASSIUM IMP. E (EP): PHENOXYMETHYLPENICILLOIC ACID MM(CRM STANDARD)
- Chemical Name:
- Penicillin G benzathine buffered
- Chemical Name:
- Penicillin G Procaine/Sodium 3:1
- Chemical Name:
- BENZYLPENICILLIN POTASSIUM IMP.E (EP):PENICILLOIC ACIDS OF BENZYLPENICILLIN MM(CRM STANDARD)
- Chemical Name:
- ACETYL-DL-PENICILLAMINE, N-(RG)
- Structure:
- Chemical Name:
- pheneticillin
- CAS:
- 147-55-7
- MF:
- C17H20N2O5S
- Chemical Name:
- Penicillin G Sodium salt
- Chemical Name:
- CYCLACILLIN USP(CRM STANDARD)
- Chemical Name:
- FURBENCILLIN SODIUM