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Penicillins drugs

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Mechanism
penicillin can inhibit the synthesis of bacterial cell wall, leading to the production and activation of autolysis enzymes, resulting in bacterial death. For this group of drugs, different varieties target on different penicillin-binding proteins and enzymes with these proteins and enzymes being involved in bacterial cell wall metabolism.

Indications
they have bactericidal effect during the reproduction period of bacteria. Gram-positive cocci: Streptococcus, pneumococcus, sensitive staphylococcus; and some kinds of gram-negative cocci: to Neisseria meningitidis, Neisseria gonorrhoeae, they have strong antibacterial effects. Clostridium bacilli: Corynebacterium diphtheriae; spirochete, Treponema pallidum, borrelia recurrentis, and Leptospira; they are also applicable to various kinds of inflection diseases caused by Clostridium bacillus, Tetanus bacilli, Clostridium welchii and actinomycetes; for example, various kinds of suppurative skin disease, skin bacterial infections, gonorrhea, syphilis and so on.

Contraindications
patients who are allergic to penicillin and have a history of allergy should be disabled.

Adverse reactions
1. Allergic reaction
2. Gastrointestinal discomfort.

Precautions
1. Probenecid can block the excretion of penicillin drugs with combination usage can cause the increase of its plasma concentration.
2. Before drug administration, people must be subject to skin test according to the provisions. Patients who are allergic to the procaine should be disabled from using the procaine penicillin.
3. Procaine penicillin can occasionally cause a specific reaction. Upon injection of drugs or after 1 ~2min, patients may get a series of symptoms such as feeling uncomfortable in the heart, getting endangered fear, dizziness, palpitations and auditory hallucinations. Generally there are no breathing disorders and circulatory disorders occurring. For the majority of cases can be elevated blood pressure. Generally this doesn’t require special treatment. The symptoms will be automatically relived after 1 ~ 2h. Application of sedatives and antihistamines can help to restore.
4. Low-dose of penicillin does not cause toxicity. Large doses of application may cause neuropsychiatric symptoms. For patients with hemagglutination defects, high-dose of penicillin can disrupt the blood clotting mechanism, thereby leading to bleeding tendency.
5. The aqueous solution of penicillin sodium and potassium salt are unstable, thus should be used now with.

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Structure:
Chemical Name:
Ampicillin
CAS:
7177-48-2
MF:
C16H25N3O7S
Structure:
Chemical Name:
WORTMANNIN
CAS:
19545-26-7
MF:
C23H24O8
Structure:
Chemical Name:
Oxacillin sodium monohydrate
CAS:
7240-38-2
MF:
C19H20N3NaO6S
Structure:
Chemical Name:
Ampicillin sodium
CAS:
69-52-3
MF:
C16H20N3NaO4S
Structure:
Chemical Name:
Procaine penicilline G hydrate
CAS:
6130-64-9
MF:
C29H38N4O6S
Structure:
Chemical Name:
Penicillin V-D5
MF:
C16H18N2O5S
Structure:
Chemical Name:
Meropenem Trihydrate
CAS:
119478-56-7
MF:
C17H27N3O6S
Chemical Name:
AMOXICILLIN AND CLAVULANATE POTASSIUM
Structure:
Chemical Name:
Penicillin G sodium salt
CAS:
69-57-8
MF:
C16H17N2NaO4S
Structure:
Chemical Name:
Sodium cloxacillin monohydrate
CAS:
7081-44-9
MF:
C19H19ClN3NaO6S
Structure:
Chemical Name:
Carbenicillin disodium
CAS:
4800-94-6
MF:
C17H19N2NaO6S
Structure:
Chemical Name:
Piperacillin sodium salt
CAS:
59703-84-3
MF:
C23H26N5NaO7S
Structure:
Chemical Name:
Cloxacillin benzathine
CAS:
23736-58-5
MF:
C35H38ClN5O5S
Structure:
Chemical Name:
Ampicillin
CAS:
69-53-4
MF:
C16H19N3O4S
Structure:
Chemical Name:
Penicillin G potassium salt
CAS:
113-98-4
MF:
C16H17KN2O4S
Chemical Name:
PENICILLINASE
CAS:
9001-74-5
Structure:
Chemical Name:
Amoxicillin
CAS:
26787-78-0
MF:
C16H19N3O5S
Structure:
Chemical Name:
Penicillin V Benzathine
CAS:
63690-57-3
MF:
C16H20N2.2C16H18N2O5S
Structure:
Chemical Name:
Piperacillin
CAS:
61477-96-1
MF:
C23H27N5O7S
Structure:
Chemical Name:
OXACILLIN
CAS:
66-79-5
MF:
C19H19N3O5S
Structure:
Chemical Name:
CARBENICILLIN
CAS:
4697-36-3
MF:
C17H18N2O6S
Structure:
Chemical Name:
Benzathine benzylpenicillin
CAS:
1538-09-6
MF:
C48H56N6O8S2
Structure:
Chemical Name:
Flucloxacillin sodium
CAS:
1847-24-1
MF:
C19H18ClFN3NaO5S
Structure:
Chemical Name:
Procaine penicillin G
CAS:
54-35-3
MF:
C29H38N4O6S
Chemical Name:
MAGNAMYCIN A PENICILLIN G
Structure:
Chemical Name:
Penicillin G
CAS:
61-33-6
MF:
C16H18N2O4S
Structure:
Chemical Name:
CHLOMETHOCILLIN
CAS:
1926-49-4
MF:
C17H18Cl2N2O5S
Structure:
Chemical Name:
Penicillin V potassium salt
CAS:
132-98-9
MF:
C16H17KN2O5S
Structure:
Chemical Name:
Azlocillin sodium
CAS:
37091-65-9
MF:
C20H22N5NaO6S
Structure:
Chemical Name:
LENAMPICILLIN
CAS:
86273-18-9
MF:
C21H23N3O7S
Structure:
Chemical Name:
PENICILLIN-STREPTOMYCIN-NEOMYCIN
MF:
C61H105N15O30S
Structure:
Chemical Name:
Amoxicillin sodium
CAS:
34642-77-8
MF:
C16H20N3NaO5S
Structure:
Chemical Name:
Mezlocillin sodium
CAS:
59798-30-0
MF:
C22H27N6NaO9S2
Structure:
Chemical Name:
Dicloxacillin sodium
CAS:
13412-64-1
MF:
C19H20Cl2N3NaO6S
Chemical Name:
Penicillin&StreptoMycin&NeoMycin solution,γ-Irradiated
Structure:
Chemical Name:
PENICILLIN V
CAS:
87-08-1
MF:
C16H18N2O5S
Structure:
Chemical Name:
METHICILLIN SODIUM (500 MG) (AS)
CAS:
7246-14-2
MF:
C17H19N2O6S.Na.H2O
Chemical Name:
PENICILLIN G ALLERGY REAGENTS
Chemical Name:
AMOXYCILLIN Sodium sterile IP/Bp
Chemical Name:
PENICILLIN G PROCAINE USP(CRM STANDARD)
Chemical Name:
PHENOXYMETHYLPENICILLIN POTASSIUM IMP. B (EP): PHENOXYACETIC ACID MM(CRM STANDARD)
Structure:
Chemical Name:
Sulbenicillin sodium
CAS:
28002-18-8
MF:
C16H16N2Na2O7S2
Structure:
Chemical Name:
OXACILLIN SODIUM
CAS:
1173-88-2
MF:
C19H18N3NaO5S
Structure:
Chemical Name:
Azlocillin
CAS:
37091-66-0
MF:
C20H23N5O6S
Structure:
Chemical Name:
Dicloxacillin
CAS:
3116-76-5
MF:
C19H17Cl2N3O5S
Chemical Name:
EC 3.5.1.11
CAS:
9014-06-6
Structure:
Chemical Name:
APALCILLIN
CAS:
63469-19-2
MF:
C25H23N5O6S
Structure:
Chemical Name:
Mecillinam
CAS:
32887-01-7
MF:
C15H23N3O3S
Structure:
Chemical Name:
Ticarcillin
CAS:
34787-01-4
MF:
C15H16N2O6S2
Structure:
Chemical Name:
N-4-BENZYLOXYPHENYL ISOBUTYRYLACETAMIDE
CAS:
265989-30-8
MF:
C19H21NO3
Structure:
Chemical Name:
Flucloxacillin
CAS:
5250-39-5
MF:
C19H17ClFN3O5S
Structure:
Chemical Name:
Nafcillin sodium salt monohydrate
CAS:
7177-50-6
MF:
C21H25N2NaO6S
Structure:
Chemical Name:
Mezlocillin
CAS:
51481-65-3
MF:
C21H25N5O8S2
Structure:
Chemical Name:
LK-PENICILLIN IN PENICILLIN G THE DERIVATIVES
CAS:
30034-13-0
MF:
C24H26N2O6S
Chemical Name:
D-PHENETHICILLIN POTASSIUM USP(CRM STANDARD)
Structure:
Chemical Name:
TICARCILLIN DISODIUM SALT
CAS:
29457-07-6
MF:
C15H17N2NaO6S2
Structure:
Chemical Name:
7-(2,2-DIMETHYL-5-OXO-4-PHENYL-IMIDAZOLIDIN-1-YL)-3,3-DIMETHYL-6-OXO-2-THIA-5-AZABICYCLO[3.2.0]HEPTANE-4-CARBOXYLIC ACID
CAS:
3511-16-8
MF:
C19H23N3O4S
Chemical Name:
Procaine penicillin G(fortified)
Chemical Name:
TALAMPICILLIN HYDROCHLORIDE EPT(CRM STANDARD)
Chemical Name:
METICILLIN SODIUM WHO(CRM STANDARD)
Structure:
Chemical Name:
BACAMPICILLIN
CAS:
50972-17-3
MF:
C21H27N3O7S
Structure:
Chemical Name:
Aspoxicillin
CAS:
63358-49-6
MF:
C21H27N5O7S
Structure:
Chemical Name:
CYCLACILLIN (200 MG)
CAS:
3485-14-1
MF:
C15H23N3O4S
Chemical Name:
Penicillin G sodium buffered
Chemical Name:
PENICILLIN G BENZATHINE USP(CRM STANDARD)
Chemical Name:
AZLOCILLIN SODIUM USP(CRM STANDARD)
Chemical Name:
BENETHAMINE PENICILLIN BP(CRM STANDARD)
Chemical Name:
BENZYLPENICILLIN BENZATHINE IMP. B (EP): PHENYLACETIC ACID G&Uuml
Chemical Name:
CLOXACILLIN BENZATHINE USP(CRM STANDARD)
Structure:
Chemical Name:
PHENETHICILLIN POTASSIUM SALT
CAS:
132-93-4
MF:
C17H19KN2O5S
Structure:
Chemical Name:
TALAMPICILLIN
CAS:
47747-56-8
MF:
C24H23N3O6S
Chemical Name:
FLUCLOXACILLIN SODIUM EPF(CRM STANDARD)
Structure:
Chemical Name:
CARBENICILLIN PHENYL SODIUM
CAS:
27025-49-6
MF:
C23H22N2O6S
Structure:
Chemical Name:
BACAMPICILLIN HYDROCHLORIDE
CAS:
37661-08-8
MF:
C21H28ClN3O7S
Chemical Name:
Penicillin G procaine/Potassium 3:1
Chemical Name:
Penicillin G potassium,non sterile
Chemical Name:
BENZATHINE BENZYLPENICILLIN EPB(CRM STANDARD)
Chemical Name:
4-HYDROXY PHENOXYMETHYLPENICILLIN EPH(CRM STANDARD)
Chemical Name:
PIVMECILLINAM HYDROCHLORIDE EPP(CRM STANDARD)
Chemical Name:
BENETHAMINE PENICILLIN
Structure:
Chemical Name:
Methicillin Sodium Salt
CAS:
132-92-3
MF:
C17H19N2NaO6S
Chemical Name:
Penicillin G mixture
Chemical Name:
PENICILLIN V POTASSIUM USP(CRM STANDARD)
Chemical Name:
PENCILLIN G SODIUM USP(CRM STANDARD)
Chemical Name:
L-PHENETHICILLIN POTASSIUM USP(CRM STANDARD)
Chemical Name:
TICARCILLIN SODIUM EPT(CRM STANDARD)
Structure:
Chemical Name:
SULBENICILLIN
CAS:
41744-40-5
MF:
C16H18N2O7S2
Structure:
Chemical Name:
almecillin
CAS:
87-09-2
MF:
C13H18N2O4S2
Chemical Name:
Carbenicillin Disodium Salt
Chemical Name:
PENICILLIN V USP(CRM STANDARD)
Chemical Name:
PHENOXYMETHYLPENICILLIN POTASSIUM IMP. E (EP): PHENOXYMETHYLPENICILLOIC ACID MM(CRM STANDARD)
Chemical Name:
Penicillin G benzathine buffered
Chemical Name:
Penicillin G Procaine/Sodium 3:1
Chemical Name:
PENICILLIN STREPTOMYCIN "GAMMA" IRRADIATED TISSUE CULTURE GRADE
Chemical Name:
BENZYLPENICILLIN POTASSIUM IMP.E (EP):PENICILLOIC ACIDS OF BENZYLPENICILLIN MM(CRM STANDARD)
Chemical Name:
ACETYL-DL-PENICILLAMINE, N-(RG)
Structure:
Chemical Name:
pheneticillin
CAS:
147-55-7
MF:
C17H20N2O5S
Chemical Name:
Penicillin G Sodium salt
Chemical Name:
CYCLACILLIN USP(CRM STANDARD)
Chemical Name:
FURBENCILLIN SODIUM