4,5,6,7-TETRABROMOBENZOTRIAZOLE Chemical Properties

Melting point:

262-266°C

Boiling point:

552.5±45.0 °C(Predicted)

Density 

2.840±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: 28 mg/mL

pka

3.87±0.40(Predicted)

form 

solid

color 

white

λmax

300nm(MeOH)(lit.)

Safety Information

WGK Germany 

3

HS Code 

29349990

MSDS

• Language:English Provider:SigmaAldrich

4,5,6,7-TETRABROMOBENZOTRIAZOLE Usage And Synthesis

Chemical Properties

Crystalline Solid

Uses

TBB is one of the most selective protein kinase inhibitors known, and when tested against a panel of 33 serine/threonine and tyrosine protein kinases, only three exhibited moderate inhibition by TBB, with Ki values one to two orders of magnitude higher than that for CK2.

Biological Activity

A cell-permeable, selective inhibitor of casein kinase-2 (CK2) (IC 50 = 0.9 and 1.6 μ M for rat liver and human recombinant CK2 respectively). Exhibits modest discrimination between CK2 subunits, with K i values ranging from 80 nM to 210 nM. Acts in an ATP/GTP-competitive manner and displays one to two orders of magnitude selectivity over a panel of 33 protein kinases.

Biochem/physiol Actions

TBB binds to the Val66 residue of casein kinase-2 and inhibits the binding of ATP/GTP. TBB is cell permeable; it induces caspase-dependent apoptosis and degrades hematopoietic lineage cell-specific protein 1 in Jurkat cells.

storage

Store at -20°C

4,5,6,7-TETRABROMOBENZOTRIAZOLE(17374-26-4)Related Product Information

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