2,6-Dichlorobenzoyl chloride Chemical Properties

Melting point:

15-17 °C

Boiling point:

142-143 °C/21 mmHg (lit.)

Density 

1.462 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.560(lit.)

Flash point:

>230 °F

storage temp. 

Inert atmosphere,2-8°C

form 

Liquid

color 

Clear colorless to light yellow or light pink

Water Solubility 

Miscible with alcohol, ether and acetone. Slightly miscible with heptane. Immiscible with water.

Sensitive 

Moisture Sensitive

BRN 

639531

InChI

InChI=1S/C7H3Cl3O/c8-4-2-1-3-5(9)6(4)7(10)11/h1-3H

InChIKey

JBLIDPPHFGWTKU-UHFFFAOYSA-N

SMILES

C(Cl)(=O)C1=C(Cl)C=CC=C1Cl

CAS DataBase Reference

4659-45-4(CAS DataBase Reference)

NIST Chemistry Reference

2,6-Dichlorobenzoyl chloride(4659-45-4)

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-27-36/37/39-45

RIDADR 

UN 3265 8/PG 2

WGK Germany 

1

F 

10-19-21

HazardClass 

8

PackingGroup 

II

HS Code 

29163900

MSDS

• Language:English Provider:2,6-Dichlorobenzoyl chloride
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2,6-Dichlorobenzoyl chloride Usage And Synthesis

Chemical Properties

Clear slightly yellow liquid

Uses

2,6-Dichlorobenzoyl chloride acts as an important intermediate in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs. It is employed in the substrate activity screening method for the rapid development of novel substrates and their conversion into non-peptidic inhibitors of Cys and Ser proteases. It is also used in the preparation of 1-acyliridoles and (-)-aspicilin. In addition to this, it undergoes esterification of (fluoren-9-ylmethoxy)carbonyl (Fmoc)-amino acids to 4-alkoxybenzyl alcohol polystyrene.

Uses

2,6-Dichlorobenzoyl chloride was used:

• in substrate activity screening method for the rapid development of novel substrates and their conversion into non-peptidic inhibitors of Cys and Ser proteases
• in the synthesis of 1-acyliridoles
• in enantiocontrolled total synthesis of (-)-aspicilin

General Description

2,6-Dichlorobenzoyl chloride participates in esterification of (fluoren-9-ylmethoxy)carbonyl (Fmoc)-amino acids to 4-alkoxybenzyl alcohol polystyrene.

Synthesis

At 0 °C and under nitrogen protection, 2,6-dichlorobenzoic acid (0.1 g, 0.52 mmol) was dissolved in dichloromethane (5 mL), N,N-dimethylformamide (3.83 mg, 52.35 μmol) was added as a catalyst, followed by the slow addition of oxalyl dichloride (0.20 g, 1.57 mmol). The reaction mixture was added dropwise at 0 °C and stirred in the range of 0 to 20 °C for 2 hours. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding reagent ratio of petroleum ether:ethyl acetate=5:1, Rf=0.77) and after confirming the complete consumption of the feedstock, the solvent was removed under reduced pressure to afford 2,6-dichlorobenzoyl chloride (0.11 g, 0.37 mmol, 70% yield), and the product was ready to be used in the next step of the reaction without further purification. 28g-int (65 mg, 0.17 mmol, in hydrochloride form) and N,N-diisopropylethylamine (DIEA, 87.3 mg, 0.68 mmol) were dissolved in dichloromethane (10 mL), and dichloromethane (5 mL) was slowly added dropwise at 0 °C and under nitrogen protection to a 2,6-dichlorobenzoyl chloride (88.43 mg, 0.42 mmol) solution. The reaction mixture was stirred at 0-20 °C for 16 h. Liquid chromatography-mass spectrometry (LCMS) analysis showed that 28g-int was completely consumed and 28h-int was produced.After removing the solvent under reduced pressure, the crude product was purified by preparative high-performance liquid chromatography (HPLC) to give pure 28h-int.LCMS (electrospray ionization in positive ion mode, ESI+) data: m/ z 521.3 ([M+H]+), retention time (RT): 1.1 min. HPLC purification conditions: a Gilson 281 semi-preparative HPLC system was used; mobile phase A: an aqueous solution containing 0.075% trifluoroacetic acid (TFA, v/v), mobile phase B: acetonitrile (ACN) with a gradient elution program (phase B ratio: 20% at 0 min, 40% at 12 min ); column: YMC-Actus Triart C18 (150 mm×30 mm, 5 μm); flow rate: 20 mL/min; detection wavelength: 220 nm and 254 nm.

Purification Methods

Reflux the acid chloride for 2hours with excess of acetyl chloride (3 volumes), distil off AcCl followed by the benzoyl chloride. Store it away from moisture. It is an IRRITANT.[Beilstein 9 III 1377.]

References

[1] Patent: WO2018/49068, 2018, A1. Location in patent: Paragraph 0430; 0431
[2] Journal of the American Chemical Society, 1940, vol. 62, p. 1432,1434
[3] Journal of the Chemical Society, 1903, vol. 83, p. 1213
[4] Journal of Medicinal Chemistry, 1991, vol. 34, # 9, p. 2843 - 2852
[5] Journal of Medicinal Chemistry, 1982, vol. 25, # 11, p. 1280 - 1286

2,6-Dichlorobenzoyl chloride(4659-45-4)Related Product Information

• Benzoyl chloride
• 4-Chlorobenzoyl chloride
• Calcium chloride
• 4-tert-Butylbenzoyl chloride
• 2-Chlorobenzoyl chloride
• Sodium chloride
• 3,5-DICHLOROBENZOYL CHLORIDE 96+%,3,5-DICHLOROBENZOYL CHLORIDE 98+%,3,5-DICHLOROBENZOYL CHLORIDE
• 2',4'-Dichloroacetophenone
• Polyvinyl chloride
• 1,2-Dichloroethane
• Benzoyl peroxide
• 2,4,6-Trichlorobenzoyl chloride
• Ferric chloride
• p-Toluoyl chloride
• 2-Fluorobenzoyl chloride
• Ammonium chloride
• Sulfuryl chloride
• Potassium chloride