Rapacuronium Chemical Properties

Melting point:

184°

alpha 

20D -12.7° (c = 1.01 in CHCl3)

storage temp. 

Store at -20°C

solubility 

DMSO : ≥ 125 mg/mL (184.42 mM)

Rapacuronium Usage And Synthesis

Description

Rapacuronium bromide was introduced in the US as a parenterally administered adjunct to general anesthesia during surgical procedures. It is a new steroidal derivative belonging to the same class as vecuronium bromide. This 2,16-bispiperidinylandrostane derivative can be synthesized in 3 steps from the 3-hydroxy-androstan-17-one analog and finally quaternized with allyl bromide. Rapacuronium bromide is a nondepolarizing neuromuscular blocking drug with a rapid onset and a short duration of action. With a relatively low potency (ED₉₀ = 1.15 mg/kg), Rapacuronium is expected to be substituted for the polarizing succinylcholine with very short duration of action.

Originator

Akzo Nobel (Netherlands)

Uses

Rapacuronium Bromide is an aminosteroidal nondepolarizing neuromuscular blocking agent and was used as a anesthesia.

brand name

Raplon

Rapacuronium(156137-99-4)Related Product Information

• CETYLDIMETHYLETHYLAMMONIUM BROMIDE
• ALLYL TRIETHYLAMMONIUM BROMIDE
• METHACHOLINE BROMIDE
• ALLYL TRIMETHYLAMMONIUM BROMIDE
• (2b,3a,16b,17b)-2,16-Bispiperidino-3,17-diacetoxy-5-androstane
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• Tetradecyltrimethylammonium bromide
• Hexadecyl trimethyl ammonium bromide
• 5a-Androstane-3a,17b-diol
• 2,16-Dipiperidin-1-ylandrosta-3,17-diol
• 2-PIPERIDIN-1-YL-CYCLOHEXANOL
• N-cyclodecylmethylamine
• N-ALLYLCYCLOPENTYLAMINE
• DIETHYL-(2-HYDROXYCYCLOHEXYL)-AMINE
• N,N''-DIMETHYL-1,12-DIAMINODODECANE
• Rapacuronium
• triethylhexadecylammonium bromide
• TRIETHYLHEXYLAMMONIUM BROMIDE