Basic information Safety Supplier Related

Rapacuronium

Basic information Safety Supplier Related

Rapacuronium Basic information

Product Name:
Rapacuronium
Synonyms:
  • Rapacuronium
  • Org 9487
  • Raplon
  • [(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-3-acetyloxy-10,13-dimethyl-2-piperidin-1-yl-16-(1-prop-2-enylpiperidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl] propanoate
CAS:
156137-99-4
MF:
C37H61BrN2O4
MW:
677.81
Mol File:
156137-99-4.mol
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Rapacuronium Chemical Properties

Melting point:
184°
alpha 
20D -12.7° (c = 1.01 in CHCl3)
storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 125 mg/mL (184.42 mM)
form 
Solid
color 
Light yellow to yellow
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Rapacuronium Usage And Synthesis

Description

Rapacuronium bromide was introduced in the US as a parenterally administered adjunct to general anesthesia during surgical procedures. It is a new steroidal derivative belonging to the same class as vecuronium bromide. This 2,16-bispiperidinylandrostane derivative can be synthesized in 3 steps from the 3-hydroxy-androstan-17-one analog and finally quaternized with allyl bromide. Rapacuronium bromide is a nondepolarizing neuromuscular blocking drug with a rapid onset and a short duration of action. With a relatively low potency (ED90 = 1.15 mg/kg), Rapacuronium is expected to be substituted for the polarizing succinylcholine with very short duration of action.

Originator

Akzo Nobel (Netherlands)

Uses

Rapacuronium Bromide is an aminosteroidal nondepolarizing neuromuscular blocking agent and was used as a anesthesia.

brand name

Raplon

RapacuroniumSupplier

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