Tetradecyltrimethylammonium bromide Chemical Properties

Melting point:

245-250 °C(lit.)

Density 

1.1328 (rough estimate)

vapor pressure 

0Pa at 25℃

refractive index 

1.5260 (estimate)

storage temp. 

Store below +30°C.

solubility 

H₂O: 10 % (w/v)

form 

Fine Crystalline Powder

color 

White

PH

pH (50g/l, 25℃ : 4.0～6.0

Water Solubility 

20 g/100 mL

Sensitive 

Hygroscopic

λmax

λ: 240 nm Amax: ≤0.08
λ: 250 nm Amax: ≤0.05
λ: 260 nm Amax: ≤0.04
λ: 500 nm Amax: ≤0.02

Merck 

14,6336

BRN 

3633227

Stability:

Stable. Hygroscopic. Incompatible with strong oxidizing agents.

InChIKey

CXRFDZFCGOPDTD-UHFFFAOYSA-M

LogP

2.2 at 20℃

CAS DataBase Reference

1119-97-7(CAS DataBase Reference)

EPA Substance Registry System

Tetradecyl trimethyl ammonium bromide (1119-97-7)

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-36/37/39-45-27

RIDADR 

UN 3263 8/PG 2

WGK Germany 

3

RTECS 

BS5776000

F 

3

TSCA 

Yes

HazardClass 

8

PackingGroup 

II

HS Code 

29239000

Toxicity

LD50 in mice, rats (mg/kg): 12.0, 15.0 i.v. (Issomaa, Bjondahl)

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Tetradecyltrimethylammonium bromide Usage And Synthesis

Physical properties

Cetrimide is a white fine powder crystal with a melting point of 245°C to 250°C. A rough estimate of its density is 1.1328. It is soluble in water with a solubility of 20 g/100 mL.

Description

MiTMAB (1119-97-7) is a dynamin I/II inhibitor targeting the dynamin-phospholipid interaction and inhibiting dynamin GTPase activity with a Ki=940nM.1 Rapidly and reversibly inhibits multiple forms of endocytosis with no acute cellular damage1. A useful pharmacological tool for studying dynamin-mediated trafficking events.2 Induces cytokinesis failure and apoptosis in human cancer cells.3 Induces cytoprotective autophagy in human Jurkat T cells.4

Uses

Myristyltrimethylammonium has been used in a study to assess a surfactant-controlled synthetic method to obtain a nanophase of mesoporous ceria-zirconia solid solution containing cationic defects in the crystalline structure.??It has also been used in a study to determine the low molecular weight of organic acids in soils and plants by capillary zone electrophoresis.

Uses

Disinfectant; deodorant; laboratory reagent.

Definition

Myristyltrimethylammonium bro-mide.

General Description

Myristyltrimethylammonium bromide is a cationic/zwitterionic type of surfactant.

Purification Methods

Crystallise the bromide from acetone or a mixture of Me2CO and >5% MeOH or Me2CO/EtOH. Wash it with diethyl ether and dry it in a vacuum oven at 60o. It is a cationic detergent. Its solubility is 1g/5g H2O. [Dearden & Wooley J Phys Chem 91 2404 1987, Shelton et al. J Am Chem Soc 68 754 1946, Beilstein 4 III 419, 4 IV 813.]

References

1) Quan et al. (2007), Myristal trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecules dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II; Mol. Pharmacol., 72 1425 2) Joshi et al. (2011), Development and validation of a stability indicating method for the enantioselective estimation of omeprazole enantiomers in the enteric-coated formulations by high performance liquid chromatography; Mol. Cancer, 104 78 3) De Beco et al. (2009), Endocytosis is required for E-cadherin redistribution at mature adherens junctions; Proc. Natl. Acad. Sci. USA, 106 7010 4) Kim et al. (2016), Inhibition of autophagy enhances dynamin inhibitor-induced apoptosis via promoting Bak activation and mitochondrial damage in human Jurkat T cells; Biochem. Biophys. Res. Commun., 478 1609

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