N,N'-Dimethylarginine
N,N'-Dimethylarginine Basic information
- Product Name:
- N,N'-Dimethylarginine
- Synonyms:
-
- (2S)-2-amino-5-[(N,N'-dimethylcarbamimidoyl)amino]pentanoic acid
- L-Arg(Me, Me)-OH (syMMetrical)
- L-Arg(Me, Me)-OH (asyMMetrical)
- Symmetric dimethylarginine
- N5-[(Dimethylamino)iminomethyl]-L-ornithine-d6
- N5-[Bis(methylamino)methylene]-L-ornithine-d6
- NG,NG’-Dimethy-L-arginine-d6
- SDMA-d6
- CAS:
- 30344-00-4
- MF:
- C8H18N4O2
- MW:
- 202.25
- Product Categories:
-
- Isotope Labelled Compounds
- Amino Acids & Derivatives
- Intermediates & Fine Chemicals
- Isotope Labeled Compounds
- Pharmaceuticals
- Mol File:
- 30344-00-4.mol
N,N'-Dimethylarginine Chemical Properties
- Boiling point:
- 353.5±52.0 °C(Predicted)
- Density
- 1.22±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO : 50 mg/mL (247.22 mM; ultrasonic and adjust pH to 3 with 1M HCl)
- form
- Orange powder.
- pka
- 2.48±0.24(Predicted)
- color
- White to off-white
- Stability:
- Very Hygroscopic
N,N'-Dimethylarginine Usage And Synthesis
Chemical Properties
Beige to Pale Yellow Solid
Uses
N,N'-Dimethylarginine is an arginine derivative; used in chronic kidney diseases. A potential endogenous nitric oxide inhibitor in dialysis.
Definition
ChEBI: A L-arginine derivative having two methyl groups at the Nomega- and N'omega-positions
in vivo
SDMA is highly stable in serum and plasma, and the assay demonstrates excellent analytical performance. In unaffected dogs, SDMA remains unchanged whereas in affected dogs, SDMA increases during disease progression, correlating strongly with an increase in sCr and decrease in GFR[3].
Chronic SDMA infusion leads to a significant increase of SDMA levels in mice, but the GFR did not change at 4 weeks. No histological changes are observed, particularly no effect on fibrosis or endothelias nitric oxide synthase expression. There is neither an effect of SDMA on systolic blood pressure nor on ejection fraction[4].
IC 50
Human Endogenous Metabolite
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