4-(cyclohexylsulfamoyl)benzoic acid Chemical Properties

Melting point:

259-260 °C

Boiling point:

473.4±47.0 °C(Predicted)

Density 

1.36±0.1 g/cm3(Predicted)

pka

3.54±0.10(Predicted)

form 

Solid

color 

White to off-white

4-(cyclohexylsulfamoyl)benzoic acid Usage And Synthesis

Description

NSC23005 is a p18INK inhibitor. NSC23005 potently promotes hematopoietic stem cell (HSC) expansion (ED50 = 5.21 nM).

Uses

INK4C-IN-2 (Compound 40) is the inhibitor for INK4C (also known as p18) and the activator for CDK4/6. INK4C-IN-2 increases the number and expansion capacity of mouse and human hematopoietic stem cells (HSCs) with EC50 of 5.21 nM, promotes the self-renewal and multilineage differentiation of HSCs. INK4C-IN-2 improves the expansion and long-term hematopoietic reconstruction ability of HSCs in mouse bone marrow transplantation model[1].

References

[1] Xie XQ, et al., Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion. Sci Rep. 2015 Dec 18;5:18115. DOI:10.1038/srep18115

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