N-(tert-Butoxycarbonyl)glycylglycine Chemical Properties

Melting point:

132 °C

Boiling point:

488.1±30.0 °C(Predicted)

Density 

1.222±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Store in freezer, under -20°C

solubility 

soluble in Methanol

form 

Powder

pka

3.41±0.10(Predicted)

color 

White

CAS DataBase Reference

31972-52-8(CAS DataBase Reference)

Safety Information

Risk Statements 

43

Safety Statements 

24/25-36/37

HS Code 

2922.19.9690

HazardClass 

IRRITANT

N-(tert-Butoxycarbonyl)glycylglycine Usage And Synthesis

Chemical Properties

White powder

Uses

Boc-Gly-Gly-OH is a Glycine.html" class="link-product" target="_blank">Glycine (HY-Y0966) derivative[1].

Synthesis

GENERAL METHODS: Amino acids or peptides (1 mmol) were added dropwise to a solution of ethanol (1 mL) containing guanidine hydrochloride (15 mmol) and di-tert-butyl dicarbonate (2.5-3 mmol) under stirring conditions, and the temperature of the reaction was maintained at 35-40°C. The reaction mixture was stirred continuously until a clarified solution was formed. Subsequently, the ethanol was removed by evaporation under reduced pressure. The residue was washed sequentially with distilled water (2 mL) and hexane or petroleum ether (2 mL) to obtain high purity N-Boc amino acids or N-Boc peptides. If further improvement of product purity is required, the crude product can be purified by recrystallization.

References

[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368

N-(tert-Butoxycarbonyl)glycylglycine(31972-52-8)Related Product Information

• Ethyl 2-(Chlorosulfonyl)acetate
• L-Alanyl-L-Glutamine
• EC 2.3.2.2
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• BOC-Glycine
• N-Carbobenzyloxyglycine
• tert-Butanol
• Glycine
• 4-Hydroxy-D-(-)-2-phenylglycine
• Phenylacetic acid
• Acetic anhydride
• BOC-VAL-GLY-OH
• BOC-GLY-PRO-OH
• BOC-LEU-PRO-OH
• BOC-ALA-ALA-OH
• BOC-GLN-PRO-OH
• BOC-ILE-GLY-OH
• BOC-PHE-PRO-OH