Glycylglycine Chemical Properties

Melting point:

220-240 °C (dec.)

Boiling point:

267.18°C (rough estimate)

Density 

1.5851 (rough estimate)

vapor pressure 

0.058Pa at 20-50℃

refractive index 

1.4880 (estimate)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

H₂O: 1 M at 20 °C, clear, colorless

pka

3.139(at 25℃)

form 

Solid

color 

White

PH

4.5-6.0 (20℃, 1M in H2O)

PH Range

7.5 - 8.9

Water Solubility 

SOLUBLE IN HOT WATER

λmax

λ: 260 nm Amax: 0.075
λ: 280 nm Amax: 0.072

Merck 

14,4503

BRN 

1765223

Stability:

Stable. Incompatible with strong oxidizing agents.

InChIKey

YMAWOPBAYDPSLA-UHFFFAOYSA-N

LogP

-0.92 at 25℃ and pH6

CAS DataBase Reference

556-50-3(CAS DataBase Reference)

NIST Chemistry Reference

N-Glycylglycine(556-50-3)

EPA Substance Registry System

Glycylglycine (556-50-3)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36

Safety Statements 

24/25-26

WGK Germany 

3

F 

10

TSCA 

Yes

HS Code 

29241900

MSDS

• Language:English Provider:N-Glycylglycine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Glycylglycine Usage And Synthesis

Chemical Properties

White crystals

Uses

Glycylglycine is as a buffering reagent and also used in biochemical research. It is the simplest of all dipeptides and is used as a starting template for preparation of more complex peptides. It is also employed as a practical buffer with a buffering range of 7.5 - 8.9 (at 25°C). Valuable agent for experiments investigating peptide transport and absorption.

Definition

ChEBI: A dipeptide formed from glycine residues.

Synthesis Reference(s)

Journal of the American Chemical Society, 75, p. 5323, 1953 DOI: 10.1021/ja01117a053

Biochem/physiol Actions

Glycine is a non-essential amino acid. Influx of calcium through the cell membrane is mediated by glycine-gated channel. Glycine participates in the synthesis of porphyrins, purine and serine. It also serves as a competitive agonist for glutamate in binding to the NMDA (N-methyl-D-aspartate) receptors. Glycine synthesis might be increased in rapidly proliferating cancer cells, due to increased demand for the amino acid. Diglycine is known to catalyze the formation of homo- and hetero dipeptides more efficiently than glycine.

Purification Methods

Crystallise glycylglycine from aqueous 50% EtOH or water at 50-60o by addition of EtOH. Dry it at 110o. It sublimes at 190-200o/0.3mm with 30% recovery [Gross & Gradsky J Am Chem Soc 77 1678 1955, King J Am Chem Soc 79 6153 1957]. [Beilstein 4 IV 2459.]

Glycylglycine(556-50-3)Related Product Information

• N-(Carboxymethyl)-N-(phosphonomethyl)-glycine
• Glutathione
• Glycine
• 9,9-Bis(4-hydroxyphenyl)fluorene
• Benzyl salicylate
• Bisphenol TMC
• Salicylanilide
• GLYCYL-L-PHENYLALANINE
• Copper Peptide
• Benzyl glycinate p-toluenesulfonate
• Copper glycinate
• Glycine tert butyl ester hydrochloride
• Glycinamide hydrochloride
• Glycine ethyl ester hydrochloride
• GLYCYL-L-PROLINE
• H-GLY-D-GLN-OH
• Glycyl-L-valine
• GLYCYL-DL-PHENYLALANINE