N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine
N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine Basic information
- Product Name:
- N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine
- Synonyms:
-
- N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine
- D-α-Glutamine, N-(N-acetylnormuramoyl)-L-alanyl-
- CAS:
- 61136-12-7
- MF:
- C18H30N4O11
- MW:
- 478.45
- Mol File:
- 61136-12-7.mol
N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine Usage And Synthesis
Uses
Almurtide (nor-MDP), a muramyl dipeptide derivative with anti-inflammatory and anti-tumor activity. Almurtide also shows protective effects against intraperitoneal Pseudomonas aeruginosa infection or intravenously Candida albicans infection in mice. Almurtide also inhibits the carcinogenic Friend leukemia virus[1][2][3].
in vivo
Almurtide (80 mg/kg; once daily for 4 consecutive days; via intraperitoneal, intravenous, or subcutaneous) stimulates macrophages nonspecifically and has anti-infective activity against Listeria monocytogenes. At the same time, it lacks oral activity and is synergistic with Gentamicin (HY-A0276A)[2].
Almurtide (100 μg/mouse; s.c.; once for 2-3 months) prevents erythroleukemia in SJL/J mice caused by low-dose Friend leukemia virus and delays the occurrence of spontaneous breast tumors in RIII/Imr mice[3].
References
[1] Díaz-Eufracio BI, et al. Exploring the chemical space of peptides for drug discovery: a focus on linear and cyclic penta-peptides. Mol Divers. 2018 May;22(2):259-267. DOI:10.1007/s11030-018-9812-9
[2] Fraser-Smith E B, et al. Protective effect of muramyl dipeptide analogs against infections of Pseudomonas aeruginosa or Candida albicans in mice. Infection and immunity, 1981, 34(3): 676-683.
[3] Acevedo H F, et al. Prevention of oncogenic viral infections in mice with CGP 11637, a synthetic muramyl dipeptide analog[J]. Antimicrobial agents and chemotherapy, 1985, 28(5): 589-596.