[NPHE1]NOCICEPTIN(1-13)NH2
[NPHE1]NOCICEPTIN(1-13)NH2 Basic information
- Product Name:
- [NPHE1]NOCICEPTIN(1-13)NH2
- Synonyms:
-
- N-(Bzl)Gly-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-NH2 (N-(Bzl)GlyN-Benzylglycine)
- N-(BZL)GLY-GLY-GLY-PHE-THR-GLY-ALA-ARG-LYS-SER-ALA-ARG-LYS-NH2
- [NPHE1]NOCICEPTIN(1-13)NH2
- [N-PHE1]-NOCICEPTIN FRAGMENT 1-13 AMIDE
- L-Lysinamide, N-(phenylmethyl)glycylglycylglycyl-L-phenylalanyl-L-threonylglycyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-alanyl-L-arginyl-
- Bzl-GGGFTGARKSARK-NH2
- N-（BN）Gly-Gly-Gly-Phe-Thr-Gly-Ala-Arg--Lys-Ser-Ala-Arg--Lys-NH2
- CAS:
- 267234-08-2
- MF:
- C61H100N22O15
- MW:
- 1381.59
- Product Categories:
-
- Neuropeptides
- Opioid Peptides
- Other Opioid Peptides
- Other Opioid PeptidesPeptides for Cell Biology
- Opioid receptor and opioid-like receptor
- Mol File:
- 267234-08-2.mol
[NPHE1]NOCICEPTIN(1-13)NH2 Chemical Properties
- Density
- 1.44±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- Soluble to 1 mg/ml in 10% acetonitrile
- form
- lyophilized powder
- pka
- 12.91±0.46(Predicted)
MSDS
- Language:English Provider:SigmaAldrich
[NPHE1]NOCICEPTIN(1-13)NH2 Usage And Synthesis
Uses
[Nphe1]Nociceptin(1-13)NH2, a novel nociceptin/orphanin FQ (NC) endogenous ligand, is a selective and competitive ociceptin receptor antagonist without any residual agonist activity. [Nphe1]nociceptin(1-13)NH2?binds selectively to recombinant nociceptin receptors (pKi=8.4) and antagonizes the inhibitory effects of nociceptin on cyclic AMP accumulation in CHO cells (pA2=6.0). [Nphe1]Nociceptin(1-13)NH2 has the potential to act as an analgesic agent[1].
References
[1] Y Hashimoto, et al. Antagonistic effects of [Nphe1]nociceptin(1-13)NH2 on nociceptin receptor mediated inhibition of cAMP formation in Chinese hamster ovary cells stably expressing the recombinant human nociceptin receptor DOI:10.1016/s0304-3940(99)00915-5
[2] G Calo', et al. Characterization of [Nphe(1)]nociceptin(1-13)NH(2), a new selective nociceptin receptor antagonist. Br J Pharmacol.?2000 Mar;129(6):1183-93. DOI:10.1038/sj.bjp.0703169
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[NPHE1]NOCICEPTIN(1-13)NH2(267234-08-2)Related Product Information
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- RRKDLHDDEEDEAMSITA
- GIP (HUMAN)
- ASN-GLU-ALA-TYR-VAL-HIS-ASP-ALA-PRO-VAL-ARG-SER-LEU-ASN
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- [NPHE1]NOCICEPTIN(1-13)NH2