QUININE HYDROBROMIDE
QUININE HYDROBROMIDE Basic information
- Product Name:
- QUININE HYDROBROMIDE
- Synonyms:
-
- QUININE HYDROBROMIDE
- 6’-methoxy-,monohydrobromide,(8-alpha,9r)-cinchonan-9-o
- bromoquinine
- chininhydrobromid
- quinine,monohydrobromide
- Quinini
- (5-ethenyl-1-azabicyclo[2.2.2]octan-7-yl)-(6-methoxyquinolin-4-yl)methanol hydrobromide
- (6-methoxy-4-quinolyl)-(5-vinylquinuclidin-2-yl)methanol hydrobromide
- CAS:
- 549-49-5
- MF:
- C20H25BrN2O2
- MW:
- 405.33
- EINECS:
- 208-967-2
- Mol File:
- 549-49-5.mol
QUININE HYDROBROMIDE Chemical Properties
- Melting point:
- 81-82 C
Safety Information
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21/22-36/37/38-42/43
- Safety Statements
- 26-36
- RIDADR
- 1544
- RTECS
- VA7650000
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29392000
QUININE HYDROBROMIDE Usage And Synthesis
Chemical Properties
yellow prisms
Uses
Quinidine hydrobromide is an antiarrhythmic agent. Quinidine is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine hydrobromide is also a K+ channel blocker with an IC50 of 19.9 μM. Quinidine hydrobromide can be used for malaria research[1][2][3].
in vivo
Quinidine hydrobromide is rapidly absorbed, with peak plasma concentrations 60-90 min after an oral dose. Other salts (gluconate, polygalacturonate) are more slowly absorbed, with lower peak concentrations[2].
Quinidine hydrobromide is approximately 70-90 % bound to plasma proteins. It undergoes hepatic oxidative metabolism to form an N-oxide, a 3-hydroxy form, an O-demethyl form and 2'-quinidinone[2].
Quinidine hydrobromide inhibits metabolism of amphetamine in rats. Quinidine hydrobromide pretreatment results in a significant decrease in the excretion of p-hydroxyamphetamine at 24 and 48 h to 7.2 and 24.1% of the vehicle-control levels, respectively, accompanied by a significant increase in amphetamine excretion between 24 and 48 h to 542% of the control[3].
References
[1] Kehl SJ, et al. Quinidine-induced inhibition of the fast transient outward K+ current in rat melanotrophs. Br J Pharmacol. 1991 Jul;103(3):1807-13. DOI:10.1111/j.1476-5381.1991.tb09867.x
[2] Roden DM, et al. Class I antiarrhythmic agents: quinidine, procainamide and N-acetylprocainamide, disopyramide. DOI:10.1016/0163-7258(83)90012-8
QUININE HYDROBROMIDESupplier
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QUININE HYDROBROMIDE(549-49-5)Related Product Information
- Quinine
- EUQUININE
- QUININE FORMATE
- Quinidine
- CINCHONIDINE HYDROCHLORIDE
- QUININE BISULFATE HEPTAHYDRATE
- CINCHONINE SULFATE
- QUINIDINE GLUCONATE
- CINCHONIDINE HYDROCHLORIDE
- CINCHONIDINE SULFATE
- Quinine sulfate dihydrate
- QUININE GLUCONATE
- HYDROQUINIDINE HYDROCHLORIDE
- CINCHONINE HYDROCHLORIDE
- QUININE HYDROBROMIDE