5-Hydroxyindole-2-carboxylic acid Chemical Properties

Melting point:

249 °C (dec.) (lit.)

Boiling point:

309.06°C (rough estimate)

Density 

1.3312 (rough estimate)

refractive index 

1.5200 (estimate)

storage temp. 

Sealed in dry,2-8°C

solubility 

chloroform/ethanol (1:1): soluble50mg/mL, clear to slightly hazy, yellow to brown

form 

Fuming Liquid

pka

4.38±0.30(Predicted)

color 

Clear colorless to slightly yellow

BRN 

153214

CAS DataBase Reference

21598-06-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-21/22

Safety Statements 

26-36-36/37/39

WGK Germany 

3

HS Code 

29339900

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

5-Hydroxyindole-2-carboxylic acid Usage And Synthesis

Chemical Properties

light yellow to beige crystalline powder

Uses

• ;Reactant for preparation of indole C5-O-substituted seco-cyclopropylindole analogs as potential anticancer agents• ;Reactant for microwave combinatorial synthesis of indolic arylpiperazine derivatives as ligands for 5-HT1A, 5-HT2A, and 5-HT2C receptors1• ;Reactant for preparation of melanins as novel nature-inspired radioprotectors2• ;Reactant for preparation of 5-Hydroxyindole-2-carboxylic acid amides as histamine-3 receptor inverse agonists for the treatment of obesity3• ;Reactant for preparation of conformationally constrained peptidomimetic inhibitors of signal

Uses

5-Hydroxyindole-2-carboxylic acid was used in HPLC-amperometric detection of serotonin in plasma, platelets and urine.

Uses

A competitive antagonist of potentiation by glycine at the N-methyl-D-aspartate receptors that have been linked to neuronal death, assiciated to such afflictions as stroke and epilepsy.

Definition

ChEBI: 5-Hydroxyindole-2-carboxylic acid is an indolyl carboxylic acid.

General Description

5-Hydroxyindole-2-carboxylic acid on oxidation with KMnO₄ yields pyrrole-2,3,5-tricarboxylic acid.

5-Hydroxyindole-2-carboxylic acid(21598-06-1)Related Product Information

• Methylparaben
• Butylparaben
• 1H-INDOL-3-OL
• Indole-2-carboxylic acid
• 5-Hydroxyindole
• 4-Hydroxybenzoic acid
• 3-Hydroxybenzoic acid
• 2'-Hydroxy-3-phenylpropiophenone
• EPA
• CHLOROPHOSPHONAZO III
• Salicylic acid
• 5-Nitropyridine-2-carboxylic acid
• 5-Chloroindole-3-carboxylic acid
• Ascoric Acid
• 5-BENZYLOXYINDOLE-2-CARBOXYLIC ACID
• ETHYL 5-BENZYLOXYINDOLE-2-CARBOXYLATE
• 5-HYDROXYINDOLE-2-CARBOXYLIC ACID ETHYL ESTER
• ETHYL 5,6-DIMETHOXYINDOLE-2-CARBOXYLATE