FPL 64176 Chemical Properties

storage temp. 

2-8°C

solubility 

DMSO: 10 mg/mL Solutions should be freshly prepared.

form 

solid

color 

tan

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

FPL 64176 Usage And Synthesis

Uses

FPL-64176 is a nondihydropyridine Ca2+ channel activator.

Definition

ChEBI: FPL 64176 is 1H-Pyrrole substituted at C-2 and -5 by methyl groups, at C-3 by methoxycarbonyl and at C-4 by a 2-benzylbenzoyl group. It has a role as a calcium channel agonist. It is a member of pyrroles and a carboxylic ester.

Biological Activity

Potent activator of L-type Ca 2+ channels (EC 50 = 16 nM). 40-fold more potent than Bay K 8644 (1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester ) as a positive inotrope in guinea pig atria.

Biochem/physiol Actions

Potent Ca2+ channel (L-type) activator.

storage

Store at RT

FPL 64176(120934-96-5)Related Product Information

• Gabapentin
• Flunarizine dihydrochloride
• Isradipine
• Cilnidipine
• Ryanodine
• Nimodipine
• CHARYBDOTOXIN
• Nicardipine hydrochloride
• DOTARIZINE
• (2R-cis)-3-acetoxy-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one monohydrochloride
• Nifedipine
• OMEGA-AGATOXIN TK
• Niguldipine (hydrochloride)
• 3-Acetyl-2,4-dimethylpyrrole
• Pyrrole-3-carboxylic acid
• Pyrrole-3-carboxylic acid
• METHYL 4-ACETYL-2,5-DIMETHYL-1H-PYRROLE-3-CARBOXYLATE
• FPL 64176