R(+)-BAY K 8644 Chemical Properties

storage temp. 

2-8°C

solubility 

H₂O: slightly soluble

form 

solid

color 

yellow

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/38

Safety Statements 

26-36

WGK Germany 

3

MSDS

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R(+)-BAY K 8644 Usage And Synthesis

Description

BAY-K-8644, originally described as a modulator of potential operated calcium channels, exists as two enantiomers that have opposite actions. (R)-(+)-BAY-K-8644 is an L-type channel blocker that has negative inotropic and vasodilatory effects at 1 μM. Intracerebroventricular administration of this enantiomer has no effect on motor function in mice, whereas (S)-(−)-BAY-K-8644 impairs rotarod and motor activity, an effect that is blocked by (R)-(+)-BAY-K-8644.

Uses

(R)-(+)-Bay K 8644 is a Ca2+ channel inhibitor, whose enantiomer is a Ca2+ channel activator.

Definition

ChEBI: (R)-Bay-K-8644 is a methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate in which the 4-position has (R)-configuration. It is an enantiomer of a (S)-Bay-K-8644.

Biological Activity

L-type Ca 2+ -channel blocker with negative inotropic and vasodilatatory effects in vivo . Enantiomer showing opposite effects to the racemate (1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester ) and (S)-(-)- enantiomer ((4S)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester ). In combination with BIX-01294, helps generate induced pluripotent stem cells (iPSCs) from mouse embryonic fibroblasts (MEFs).

storage

Store at +4°C

R(+)-BAY K 8644(98791-67-4)Related Product Information

• 2-methyl-1-nitropropane
• 3-[o-(alpha,alpha,alpha-trifluorotolyl)]propionic acid
• Phenibut
• 4-AMINO-3-PHENYL-1-BUTANOL
• 3-(2-TRIFLUOROMETHYL-PHENYL)-PROPIONALDEHYDE
• METHYL 4-NITROBUTYRATE
• o-(trifluoromethyl)phenethylamine
• BETA-(NITROMETHYL)-BENZENEPROPANOIC ACID
• 1-NITRO-2-METHYL-BUTANE
• R(+)-BAY K 8644
• 3-(2-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL
• (+/-)-BAY K8644 CALCIUM SLOW CHANNEL,(RS)-BAY K 8644,BAY K-8644 (+/-),(+/-)-BAY K 8644
• 3-[(2-TRIFLUOROMETHYL)PHENYL]-1-PROPENE
• BAY K-8644 (+/-),(+/-)-BAY K 8644
• S(-)-BAY K 8644 CA2+ CHANNEL ACTIVATO,S(-)-BAY K 8644
• R(+)-BAY K 8644 CALCIUM CHANNEL
• (+-)-CAGED BAY K 8644
• 3-METHYL-4-NITRO-BUTYRALDEHYDE