Basic information Safety Supplier Related

R(+)-BAY K 8644

Basic information Safety Supplier Related

R(+)-BAY K 8644 Basic information

Product Name:
R(+)-BAY K 8644
Synonyms:
  • (4R)-1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-[(2-TRIFLUOROMETHYL)PHENYL]-3-PYRIDINECARBOXYLIC ACID METHYL ESTER
  • R-(+)-1,4-DIHYDRO-2,6-DIMETHY-5-NITRO-(2-[TRIFLUOROMETHYL]-PHENYL)-3-PYRIDINE CARBOXYLIC ACID METHYL ESTER
  • R(+)-BAY K 8644
  • R(+)-BAY K 8644 CA2(+) CHANNEL BLOCKE
  • (+/-)-BAY K 8644, 0 TO 5 °C
  • R(+)-BAY K 8644 98% 0 C
  • (4R)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethyl)phenyl)-3-pyridinecarboxylicacidmethylester
  • r-(+)-1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester
CAS:
98791-67-4
MF:
C16H15F3N2O4
MW:
356.3
Product Categories:
  • Calcium channel
Mol File:
98791-67-4.mol
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R(+)-BAY K 8644 Chemical Properties

storage temp. 
2-8°C
solubility 
H2O: slightly soluble
form 
solid
color 
yellow
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/38
Safety Statements 
26-36
WGK Germany 
3

MSDS

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R(+)-BAY K 8644 Usage And Synthesis

Description

BAY-K-8644, originally described as a modulator of potential operated calcium channels, exists as two enantiomers that have opposite actions. (R)-(+)-BAY-K-8644 is an L-type channel blocker that has negative inotropic and vasodilatory effects at 1 μM. Intracerebroventricular administration of this enantiomer has no effect on motor function in mice, whereas (S)-(−)-BAY-K-8644 impairs rotarod and motor activity, an effect that is blocked by (R)-(+)-BAY-K-8644.

Uses

(R)-(+)-Bay K 8644 is a Ca2+ channel inhibitor, whose enantiomer is a Ca2+ channel activator.

Definition

ChEBI: (R)-Bay-K-8644 is a methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate in which the 4-position has (R)-configuration. It is an enantiomer of a (S)-Bay-K-8644.

Biological Activity

L-type Ca 2+ -channel blocker with negative inotropic and vasodilatatory effects in vivo . Enantiomer showing opposite effects to the racemate (1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester ) and (S)-(-)- enantiomer ((4S)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester ). In combination with BIX-01294, helps generate induced pluripotent stem cells (iPSCs) from mouse embryonic fibroblasts (MEFs).

storage

Store at +4°C

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