Ganoderic acid D Chemical Properties

Boiling point:

688.3±55.0 °C(Predicted)

Density 

1.22±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C, protect from light

solubility 

Soluble in methanol;

form 

powder

pka

4.77±0.23(Predicted)

color 

White

Water Solubility 

insoluble in water

Ganoderic acid D Usage And Synthesis

Chemical Properties

White powder, soluble in organic solvents such as methanol, ethanol, and DMSO. It is derived from the dried fruiting body of Ganoderma lucidum (Leyss. exFr.) Karst. of the Polyporaceae family.

Uses

Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells[1]. Ganoderic acid D induces HeLa human cervical carcinoma apoptosis[2].

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biological Activity

Ganoderic acid D is one of major triterpenes isolated from Ganoderma lucidum th at exhibit potent anticancer properties. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate, and pyruvate and acetyl-coenzyme production through SIRT3 upregulation via acetylated cyclophilin D inhibition.

IC 50

SIRT3

References

[1] Liu Z, et al. Effect of ganoderic acid D on colon cancer Warburg effect: Role of SIRT3/cyclophilin D. Eur J Pharmacol. 2018 Apr 5;824:72-77. DOI:10.1016/j.ejphar.2018.01.026
[2] Yue QX, et al. Proteomics characterization of the cytotoxicity mechanism of ganoderic acid D and computer-automated estimation of the possible drug target network. Mol Cell Proteomics. 2008 May;7(5):949-61. DOI:10.1074/mcp.M700259-MCP200

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