LEE011 (succinate)
LEE011 (succinate) Basic information
- Product Name:
- LEE011 (succinate)
- Synonyms:
-
- LEE011 (succinate)
- 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide succinate
- LEE-011 succinate salt, Ribociclib succinate salt
- Ribociclib succinate
- Ribociclib Succinate (Kisqali)
- RIBOCICLIB SUCCINATE (LEE011 SUCCINATE)
- Ribociclib succite
- RIBOCICLIB SUCCINATE (LEE011)
- CAS:
- 1374639-75-4
- MF:
- C27H36N8O5
- MW:
- 552.64
- Mol File:
- 1374639-75-4.mol
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LEE011 (succinate) Chemical Properties
- Melting point:
- >160oC (dec.)
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Pale Beige
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LEE011 (succinate) Usage And Synthesis
Uses
LEE011 is an orally bioavailable and highly specific CDK4/6 (cyclin-dependent kinase 4/6) inhibitor. LEE011 in combination with LGX818 (a V600E BRAF specific inhibitor) or BYL719 (a PIK3CA specific inhibitor) leads to robust anti-tumor activity in melanoma and breast cancer tumor models.
LEE011 (succinate)Supplier
Shanghai Yu Ben Biotechnology Co., Ltd. Gold
- Tel
- 15502154572
- yuben012@sina.com
Shanghai YiWen Pharmaceutical Co., Ltd. Gold
- Tel
- 13621628489
- 1322392736@qq.com
Synches Co., Ltd.
- Tel
- 021-53292253
- biz@synches.com
Tianjin Branch Chong pharmaceutical intermediates Co., Ltd.
- Tel
- 022-60116533 13207668525
- saleskc@scipharmacn.com
Suzhou Carbonwell Pharma-Tech Co., Ltd
- Tel
- 0512-0512-88981216 13776013740
- 1320558046@qq.com
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LEE011 (succinate)(1374639-75-4)Related Product Information
- tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
- LEE011 (hydrochloride)
- Ribociclib
- Neratinib Maleate
- 1-Piperazinecarboxylic acid, 4-[6-[[7-cyclopentyl-6-[(diMethylaMino)carbonyl]-7H-pyrrolo[2,3-d]pyriMidin-2-yl]aMino]-3-pyridinyl]-, 1,1-diMethylethyl ester
- 2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide